doi: 10.1126/science.275.5300.661.
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Affiliations
- PMID: 9005851
- DOI: 10.1126/science.275.5300.661
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Regulation of neuronal survival by the serine-threonine protein kinase Akt
Science.
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Abstract
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70(S6K)). Experiments with pharmacological inhibitors, as well as expression of wild-type and dominant-inhibitory forms of Akt, demonstrated that Akt but not p70(S6K) mediates PI3-K-dependent survival. These findings suggest that in the developing nervous system, Akt is a critical mediator of growth factor-induced neuronal survival.
Comment in
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Akt signaling: linking membrane events to life and death decisions.Science. 1997 Jan 31;275(5300):628-30. doi: 10.1126/science.275.5300.628. Science. 1997. PMID: 9019819 Review. No abstract available.
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