doi: 10.1152/ajpheart.1996.271.5.H2183.
Cardiomyocyte DNA synthesis and binucleation during murine development
Affiliations
- PMID: 8945939
- DOI: 10.1152/ajpheart.1996.271.5.H2183
Item in Clipboard
Cardiomyocyte DNA synthesis and binucleation during murine development
Am J Physiol.
1996 Nov.
Abstract
Cardiomyocyte DNA synthesis and binucleation indexes were determined during murine development. Cardiomyocyte DNA synthesis occurred in two temporally distinct phases. The first phase occurred during fetal life and was associated exclusively with cardiomyocyte proliferation. The second phase occurred during early neonatal life and was associated with binucleation. Collectively, these results suggest that cardiomyocyte reduplication ceases during late fetal life. Northern and Western blot analyses identified several candidate genes that were differentially expressed during the reduplicative and binucleation phases of cardiomyocyte growth.
Similar articles
-
Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts.Am J Physiol. 1997 Jan;272(1 Pt 2):H220-6. doi: 10.1152/ajpheart.1997.272.1.H220. Am J Physiol. 1997. PMID: 9038941
-
Mechanical stimulation of organogenic cardiomyocyte growth in vitro.Am J Physiol. 1996 May;270(5 Pt 1):C1284-92. doi: 10.1152/ajpcell.1996.270.5.C1284. Am J Physiol. 1996. PMID: 8967427
-
Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product.Am J Physiol. 1997 Sep;273(3 Pt 2):H1619-27. doi: 10.1152/ajpheart.1997.273.3.H1619. Am J Physiol. 1997. PMID: 9321857
-
Neonatal rat cardiomyocytes--a model for the study of morphological, biochemical and electrophysiological characteristics of the heart.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2001 Dec;145(2):49-55. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2001. PMID: 12426771 Review.
-
Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals.J Am Heart Assoc. 2021 Jan 19;10(2):e017839. doi: 10.1161/JAHA.120.017839. Epub 2021 Jan 5. J Am Heart Assoc. 2021. PMID: 33399005 Free PMC article. Review.
Cited by
-
Cell Cycle Withdrawal Limit the Regenerative Potential of Neonatal Cardiomyocytes.Cardiovasc Eng Technol. 2021 Oct;12(5):475-484. doi: 10.1007/s13239-021-00551-w. Epub 2021 May 27. Cardiovasc Eng Technol. 2021. PMID: 34046845
-
Differential regenerative capacity of neonatal mouse hearts after cryoinjury.Dev Biol. 2015 Mar 1;399(1):91-99. doi: 10.1016/j.ydbio.2014.12.018. Epub 2014 Dec 31. Dev Biol. 2015. PMID: 25555840 Free PMC article.
-
Timing of cardiomyocyte growth, maturation, and attrition in perinatal sheep.FASEB J. 2015 Oct;29(10):4346-57. doi: 10.1096/fj.15-272013. Epub 2015 Jul 2. FASEB J. 2015. PMID: 26139099 Free PMC article.
-
The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation.Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2139-47. doi: 10.1152/ajpheart.00063.2012. Epub 2012 Mar 16. Am J Physiol Heart Circ Physiol. 2012. PMID: 22427524 Free PMC article. Review.
-
Cardiac Regeneration and Stem Cells.Physiol Rev. 2015 Oct;95(4):1189-204. doi: 10.1152/physrev.00021.2014. Physiol Rev. 2015. PMID: 26269526 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
