Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1996 Nov;40(11):2626-31.
doi: 10.1128/AAC.40.11.2626.

Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice

R W Sidwell  1 , J H Huffman, K W Bailey, M H Wong, A Nimrod, A Panet
Affiliations

Inhibitory effects of recombinant manganese superoxide dismutase on influenza virus infections in mice

R W Sidwell et al. Antimicrob Agents Chemother. 1996 Nov.

Abstract

The oxygen free-radical scavenger recombinant human manganese superoxide dismutase (MnSOD) was studied for its effects on influenza virus infections in mice when used alone and in combination with ribavirin. Mice challenged with influenza A/NWS/33 (H1N1) virus were treated parenterally in doses of 25, 50, and 100 mg/kg of body weight per day every 8 h for 5 days beginning at 48 h post-virus exposure. An increase in mean day to death, lessened decline in arterial oxygen saturation, and reduced lung consolidation and lung virus titers occurred in the treated animals. To determine the influence of viral challenge, experiments were run in which mice were infected with a 100 or 75% lethal dose of virus and were treated intravenously once daily for 5 days beginning 96 h after virus exposure. Weak inhibition of the mortality rate was seen in mice receiving the high viral challenge, whereas significant inhibition occurred in the animals infected with the lower viral challenge, indicating that MnSOD effects are virus dose dependent. To determine if treatment with small-particle aerosol would render an antiviral effect, infected mice were treated by this route for 1 h daily for 5 days beginning 72 h after virus exposure. A dose-responsive disease inhibition was seen. An infection induced by influenza B/Hong Kong/5/72 virus in mice was mildly inhibited by intravenous MnSOD treatment as seen by increased mean day to death, lessened arterial oxygen saturation decline, and lowered lung consolidation. MnSOD was well tolerated in all experiments. A combination of MnSOD and ribavirin, each administered with small-particle aerosol, resulted in a generally mild improvement of the disease induced by the influenza A virus compared with use of either material alone.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Appl Environ Microbiol. 1976 Jan;31(1):35-8 - PubMed
    1. Chemotherapy. 1995 Nov-Dec;41(6):455-61 - PubMed
    1. Ann Rheum Dis. 1983 Feb;42(1):89-93 - PubMed
    1. Am Rev Respir Dis. 1983 Sep;128(3):552-9 - PubMed
    1. Antiviral Res. 1986 Oct;6(6):343-53 - PubMed

Publication types

MeSH terms

LinkOut - more resources