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Case Reports
. 1996 Nov;47(5):1180-3.
doi: 10.1212/wnl.47.5.1180.

Nonmotor fluctuations in patients with Parkinson's disease

M E Hillen  1 , J I Sage
Affiliations
Case Reports

Nonmotor fluctuations in patients with Parkinson's disease

M E Hillen et al. Neurology. 1996 Nov.

Abstract

We studied the nature and frequency of nonmotor "off" phenomena in 130 consecutive patients with Parkinson's disease (PD) with motor fluctuations. Twenty-two patients (17%) experienced nonmotor fluctuations as an end-of-dose phenomenon. Previously unreported, or little appreciated, nonmotor "off" states include sensory dyspnea, nausea, facial flushing, cough, hunger, unilateral limb edema, proximal limb pain, and trigeminal neuralgia-like pain. We attempted treatment modification in 12 of 22 patients; nonmotor "off" symptoms improved in nine of these 12 patients (75%). Recognizing these phenomena will prevent unnecessary tests and treatments.

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