Inhibition of monoamine oxidase B in the brains of smokers
- PMID: 8602220
- DOI: 10.1038/379733a0
Inhibition of monoamine oxidase B in the brains of smokers
Abstract
The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders and is associated with a decreased risk of Parkinson's disease. Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species. We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.
Comment in
-
Neuropharmacology. Psychoactive smoke.Nature. 1996 Feb 22;379(6567):677-8. doi: 10.1038/379677a0. Nature. 1996. PMID: 8602211 No abstract available.
Similar articles
-
Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition.J Addict Dis. 1998;17(1):23-34. doi: 10.1300/J069v17n01_03. J Addict Dis. 1998. PMID: 9549600
-
Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms.Nicotine Tob Res. 2001 Nov;3(4):383-90. doi: 10.1080/14622200110087277. Nicotine Tob Res. 2001. PMID: 11694206 Clinical Trial.
-
Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors.Biochem Biophys Res Commun. 2005 Jan 14;326(2):378-86. doi: 10.1016/j.bbrc.2004.11.033. Biochem Biophys Res Commun. 2005. PMID: 15582589
-
Tobacco leaf, smoke and smoking, MAO inhibitors, Parkinson's disease and neuroprotection; are there links?Neurotoxicology. 2004 Jan;25(1-2):279-91. doi: 10.1016/S0161-813X(03)00107-4. Neurotoxicology. 2004. PMID: 14697903 Review.
-
Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction.Life Sci. 2006 Oct 19;79(21):1969-73. doi: 10.1016/j.lfs.2006.06.010. Epub 2006 Jun 15. Life Sci. 2006. PMID: 16884739 Review.
Cited by
-
Exploring the Link between Altitude of Residence and Smoking Patterns in the United States.Int J Environ Res Public Health. 2024 Feb 14;21(2):226. doi: 10.3390/ijerph21020226. Int J Environ Res Public Health. 2024. PMID: 38397715 Free PMC article.
-
Clearing the Smoke: What Protects Smokers from Parkinson's Disease?Mov Disord. 2024 Feb;39(2):267-272. doi: 10.1002/mds.29707. Epub 2024 Jan 16. Mov Disord. 2024. PMID: 38226487 Free PMC article. Review.
-
Risk factors associated with age at onset of Parkinson's disease in the UK Biobank.NPJ Parkinsons Dis. 2024 Jan 2;10(1):3. doi: 10.1038/s41531-023-00623-9. NPJ Parkinsons Dis. 2024. PMID: 38167894 Free PMC article.
-
Lifestyle Modulators of Neuroplasticity in Parkinson's Disease: Evidence in Human Neuroimaging Studies.CNS Neurol Disord Drug Targets. 2024;23(5):602-613. doi: 10.2174/1871527322666230616121213. CNS Neurol Disord Drug Targets. 2024. PMID: 37326116 Review.
-
β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO).Molecules. 2023 Mar 17;28(6):2723. doi: 10.3390/molecules28062723. Molecules. 2023. PMID: 36985694 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
