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Review
. 1995 Sep;15(5):217-31.
doi: 10.1007/BF01540879.

Role of apoptosis in HIV disease pathogenesis

N Oyaizu  1 , S Pahwa
Affiliations
Review

Role of apoptosis in HIV disease pathogenesis

N Oyaizu et al. J Clin Immunol. 1995 Sep.

Abstract

After approximately one and a half decades of intensive studies, the exact mechanisms to explain HIV-mediated cytopathicity are still enigmatic and need closer scrutiny. There has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing a killing of infected cells by HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis. Accumulating evidence points to the notion that apoptosis might be a major contributor to the depletion of CD4 T-cells in HIV infection. This review summarizes current information about the regulatory mechanisms of T-cell apoptosis and the role of apoptosis in HIV pathogenesis with the goal of providing an integrated view of HIV cytopathicity.

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References

    1. Proc Natl Acad Sci U S A. 1985 Dec;82(23):8198-202 - PubMed
    1. Cell. 1995 Jan 27;80(2):285-91 - PubMed
    1. Cell. 1993 Aug 27;74(4):597-608 - PubMed
    1. J Exp Med. 1993 Aug 1;178(2):427-38 - PubMed
    1. Cell. 1988 May 6;53(3):483-96 - PubMed

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