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. 1995 Oct;15(5):384-90.
doi: 10.1046/j.1468-2982.1995.1505384.x.

Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally

V Gallai  1 , P Sarchielli, A Floridi, M Franceschini, M Codini, G Glioti, A Trequattrini, R Palumbo
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Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally

V Gallai et al. Cephalalgia. 1995 Oct.

Abstract

We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) and neurokinin A (NKA) in the plasma of 30 young migraine patients with aura (MPA) and 45 migraine patients without aura (MWA), and compared the results with those of 30 age-matched controls. There were no significant differences between the levels of these vasoactive peptides in the control group and the levels in both migraine groups studied in headache-free periods. An elevation of CGRP levels in plasma was found during attacks in MPA and, to a lesser extent, in MWA (p < 0.03 and p < 0.05, respectively). A significant increase in NKA levels was also demonstrated in the MPA and MWA groups (p < 0.02 and p < 0.04, respectively). These data suggest, although indirectly, that CGRP and NKA could be involved in the pathogenesis of migraine attacks in juvenile migraine patients.

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