doi: 10.1126/science.7997879.
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
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- PMID: 7997879
- DOI: 10.1126/science.7997879
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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
Science.
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Abstract
Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.
Comment in
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Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients.Science. 1995 Apr 28;268(5210):582-3. doi: 10.1126/science.7725108. Science. 1995. PMID: 7725108 No abstract available.
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AIDS-associated Kaposi's sarcoma.Science. 1995 Feb 24;267(5201):1078-9. doi: 10.1126/science.7855583. Science. 1995. PMID: 7855583 No abstract available.
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Is a new virus the cause of KS?Science. 1994 Dec 16;266(5192):1803-4. doi: 10.1126/science.7997874. Science. 1994. PMID: 7997874 No abstract available.
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