[Antiviral effect of recombinant interferon-alpha on hepatitis A virus replication in human liver cells]
[Article in
French]
Affiliations
- PMID: 7987698
Item in Clipboard
[Antiviral effect of recombinant interferon-alpha on hepatitis A virus replication in human liver cells]
[Article in
French]
C R Acad Sci III.
1994 Jan.
Abstract
Two recombinant interferons-alpha (IFNs-alpha) were assayed for their antiviral effect on hepatitis A virus (HAV) replication in the human hepatoma cell line PLC/PRF/5. IFN alpha-2a and IFN alpha-2b resulted in concentration-dependent inhibition of HAV antigen expression and HAV infectivity at non toxic concentrations. Their selectivity indices, calculated as the ratio of the dose that reduced the number of viable cells to 50% (CD50) to the effective dose that inhibited 50% of viral antigen expression (ED50) were > 1000. Recombinant IFN-alpha emerged, from the present study, as a promising candidate for chemotherapy of hepatitis A.
Similar articles
-
Antiviral activity of recombinant interferon-alpha on hepatitis A virus replication in human liver cells.Antiviral Res. 1995 Sep;28(1):69-80. doi: 10.1016/0166-3542(95)00039-o. Antiviral Res. 1995. PMID: 8585761
-
Antiviral activity of carrageenan on hepatitis A virus replication in cell culture.Res Virol. 1991 Jul-Aug;142(4):261-70. doi: 10.1016/0923-2516(91)90011-q. Res Virol. 1991. PMID: 1665574
-
Inhibition of hepatitis A virus replication in vitro by antiviral compounds.J Med Virol. 1990 Jun;31(2):155-60. doi: 10.1002/jmv.1890310214. J Med Virol. 1990. PMID: 2167349
-
Hepatitis A.Adv Virus Res. 1987;32:129-69. doi: 10.1016/s0065-3527(08)60476-5. Adv Virus Res. 1987. PMID: 3039812 Review. No abstract available.
-
The attachment receptor for hepatitis A virus.Trends Microbiol. 1997 Feb;5(2):45-7; discussion 47-8. doi: 10.1016/S0966-842X(96)30043-7. Trends Microbiol. 1997. PMID: 9108928 Review. No abstract available.
Cited by
-
Identification of Mulberrofuran as a potent inhibitor of hepatitis A virus 3Cpro and RdRP enzymes through structure-based virtual screening, dynamics simulation, and DFT studies.Mol Divers. 2024 Jun;28(3):1609-1628. doi: 10.1007/s11030-023-10679-7. Epub 2023 Jun 29. Mol Divers. 2024. PMID: 37386350
-
Treatment Options for Hepatitis A and E: A Non-Systematic Review.Viruses. 2023 Apr 28;15(5):1080. doi: 10.3390/v15051080. Viruses. 2023. PMID: 37243166 Free PMC article. Review.
-
Hepatitis A: Epidemiology, High-Risk Groups, Prevention and Research on Antiviral Treatment.Viruses. 2021 Sep 22;13(10):1900. doi: 10.3390/v13101900. Viruses. 2021. PMID: 34696330 Free PMC article. Review.