Review
doi: 10.1016/0167-5699(94)90193-7.
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells
Affiliations
- PMID: 7945773
- DOI: 10.1016/0167-5699(94)90193-7
Item in Clipboard
Review
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells
Immunol Today.
1994 Oct.
Abstract
CD69 was initially described as being restricted to recently activated lymphoid cells, but is now known to be expressed on the surface of all hematopoietically derived leukocytes. Crosslinking of CD69 generates intracellular signals in all cell lineages studied, both mouse and human, and results in a variety of cellular end responses. Since a specific ligand has not yet been identified, a definite functional identity for CD69 is still missing. However, as discussed here by Roberto Testi and colleagues, the broad expression of CD69 and its conserved ability to generate intracellular signals suggests a general role for the CD69 receptor in the biology of hematopoietic cells.
Similar articles
-
CD69-triggered ERK activation and functions are negatively regulated by CD94 / NKG2-A inhibitory receptor.Eur J Immunol. 2000 Feb;30(2):644-51. doi: 10.1002/1521-4141(200002)30:2<644::AID-IMMU644>3.0.CO;2-H. Eur J Immunol. 2000. PMID: 10671222
-
Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells.J Immunol. 2002 Jul 1;169(1):68-74. doi: 10.4049/jimmunol.169.1.68. J Immunol. 2002. PMID: 12077230
-
Anti-CD69 autoantibodies cross-react with low density lipoprotein receptor-related protein 2 in systemic autoimmune diseases.J Immunol. 2001 Jan 15;166(2):1360-9. doi: 10.4049/jimmunol.166.2.1360. J Immunol. 2001. PMID: 11145721
-
CD69: from activation marker to metabolic gatekeeper.Eur J Immunol. 2017 Jun;47(6):946-953. doi: 10.1002/eji.201646837. Eur J Immunol. 2017. PMID: 28475283 Free PMC article. Review.
-
CD69 and regulation of the immune function.Immunopharmacol Immunotoxicol. 1999 Aug;21(3):565-82. doi: 10.3109/08923979909007126. Immunopharmacol Immunotoxicol. 1999. PMID: 10466080 Review.
Cited by
-
Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production.PLoS Pathog. 2016 Sep 23;12(9):e1005839. doi: 10.1371/journal.ppat.1005839. eCollection 2016 Sep. PLoS Pathog. 2016. PMID: 27662621 Free PMC article. Clinical Trial.
-
Gammadelta T cells in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS).Clin Exp Immunol. 1999 Dec;118(3):451-7. doi: 10.1046/j.1365-2249.1999.01069.x. Clin Exp Immunol. 1999. PMID: 10594567 Free PMC article.
-
Soluble peptide-MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules.Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13729-34. doi: 10.1073/pnas.212515299. Epub 2002 Oct 8. Proc Natl Acad Sci U S A. 2002. PMID: 12374859 Free PMC article.
-
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.J Immunol. 2010 Mar 15;184(6):2793-804. doi: 10.4049/jimmunol.0902846. Epub 2010 Feb 8. J Immunol. 2010. PMID: 20142358 Free PMC article.
-
NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development.Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16091-6. doi: 10.1073/pnas.1215934110. Epub 2013 Sep 16. Proc Natl Acad Sci U S A. 2013. PMID: 24043824 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
