doi: 10.1038/373123a0.
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Affiliations
- PMID: 7816094
- DOI: 10.1038/373123a0
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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Nature.
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Abstract
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immunodeficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 +/- 0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes.
Comment in
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HIV results in the frame. HIV an illusion.Nature. 1995 May 18;375(6528):197; author reply 198. doi: 10.1038/375197b0. Nature. 1995. PMID: 7605485 No abstract available.
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HIV results in the frame. Results confirmed.Nature. 1995 May 18;375(6528):193. doi: 10.1038/375193a0. Nature. 1995. PMID: 7746311 No abstract available.
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HIV results in the frame. CD4+ cell turnover.Nature. 1995 May 18;375(6528):193-4; author reply 198. doi: 10.1038/375193b0. Nature. 1995. PMID: 7746312 No abstract available.
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HIV results in the frame. CD4+ cell turnover.Nature. 1995 May 18;375(6528):194; author reply 198. doi: 10.1038/375194a0. Nature. 1995. PMID: 7746313 No abstract available.
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HIV results in the frame. CD4+ cell turnover.Nature. 1995 May 18;375(6528):194-5; author reply 198. doi: 10.1038/375194b0. Nature. 1995. PMID: 7746314 No abstract available.
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HIV results in the frame. Antiviral therapy.Nature. 1995 May 18;375(6528):195; author reply 198. doi: 10.1038/375195a0. Nature. 1995. PMID: 7746315 No abstract available.
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HIV results in the frame. Other approaches.Nature. 1995 May 18;375(6528):195-6; author reply 198. doi: 10.1038/375195b0. Nature. 1995. PMID: 7746316 No abstract available.
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HIV results in the frame. Paradox remains.Nature. 1995 May 18;375(6528):196; author reply 198. doi: 10.1038/375196a0. Nature. 1995. PMID: 7746317 No abstract available.
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HIV results in the frame. HIV an illusion.Nature. 1995 May 18;375(6528):197; author reply 198. doi: 10.1038/375197a0. Nature. 1995. PMID: 7746319 No abstract available.
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HIV results in the frame. Toxic shock.Nature. 1995 May 18;375(6528):197-8; author reply 198. doi: 10.1038/375197c0. Nature. 1995. PMID: 7746320 No abstract available.
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HIV results in the frame. Cyclosporin A.Nature. 1995 May 18;375(6528):198; author reply 198. doi: 10.1038/375198a0. Nature. 1995. PMID: 7746321 No abstract available.
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AIDS. Virological mayhem.Nature. 1995 Jan 12;373(6510):102. doi: 10.1038/373102a0. Nature. 1995. PMID: 7816085 No abstract available.
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