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. 1995 Dec;1(12):1284-90.
doi: 10.1038/nm1295-1284.

In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency

T W Chun  1 , D Finzi, J Margolick, K Chadwick, D Schwartz, R F Siliciano
Affiliations

In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency

T W Chun et al. Nat Med. 1995 Dec.

Abstract

Although it is presumed that the integration of HIV-1 into the genome of infected CD4+ T lymphocytes allows viral persistence, there has been little direct evidence that CD4+ T cells with integrated provirus function as a latent reservoir for HIV-1 in infected individuals. Using resting CD4+ T-cell populations of extremely high purity and a novel assay that selectively and unambiguously detects integrated HIV-1, we show that resting CD4+ T cells harbouring integrated provirus are present in some infected individuals. However, these cells do not accumulate within the circulating pool of resting CD4+ T cells in the early stages of HIV-1 infection and do not accumulate even after prolonged periods in long-term survivors of HIV-1 infection. These results suggest that because of viral cytopathic effects and/or host effector mechanisms, productively infected CD4+ T cells do not generally survive for long enough to revert to a resting memory state in vivo.

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