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. 1995 Dec;1(12):1274-8.
doi: 10.1038/nm1295-1274.

Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells

C Boshoff  1 , T F Schulz, M M Kennedy, A K Graham, C Fisher, A Thomas, J O McGee, R A Weiss, J J O'Leary
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Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells

C Boshoff et al. Nat Med. 1995 Dec.

Abstract

Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus in KS tumour tissue. Using PCR in situ hybridization (PCR-ISH) we show that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells. These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions.

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