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. 1985 Nov 11;13(21):7795-812.
doi: 10.1093/nar/13.21.7795.

Respiratory syncytial virus envelope glycoprotein (G) has a novel structure

M Satake, J E Coligan, N Elango, E Norrby, S Venkatesan
Free PMC article

Respiratory syncytial virus envelope glycoprotein (G) has a novel structure

M Satake et al. Nucleic Acids Res. .
Free PMC article

Abstract

Amino acid sequence of human respiratory syncytial virus envelope glycoprotein (G) was deduced from the DNA sequence of a recombinant plasmid and confirmed by limited amino acid microsequencing of purified 90K G protein. The calculated molecular mass of the protein encoded by the only long open reading frame of 298 amino acids was 32,588 daltons and was somewhat smaller than the 36K polypeptide translated in vitro from mRNA selected by this plasmid. Inspection of the sequence revealed a single hydrophobic domain of 23 amino acids capable of membrane insertion at 41 residues from the N-terminus. There was no N-terminal signal sequence and the hydrophilic N-terminal 20 residues probably represent the cytoplasmic tail of the protein. The N-terminally oriented membrane insertion was somewhat analogous to paramyxovirus hemagglutinin-neuraminidase (HN) and influenza neuraminidase (NA). The protein was moderately hydrophilic and rich in hydroxy-amino acids. It was both N- and O-glycosylated with the latter contributing significantly to the net molecular mass 90K.

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References

    1. Eur J Biochem. 1981 Apr;115(2):335-45 - PubMed
    1. Virology. 1985 Mar;141(2):283-91 - PubMed
    1. Virology. 1981 Dec;115(2):334-44 - PubMed
    1. Virology. 1982 Jun;119(2):288-97 - PubMed
    1. Arch Gesamte Virusforsch. 1967;21(1):71-7 - PubMed