doi: 10.1038/318533a0.
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
- PMID: 3906410
- DOI: 10.1038/318533a0
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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Nature.
1985 Dec.
Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.
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