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. 2024 May 16;216(3):262-271.
doi: 10.1093/cei/uxae014.

Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction

Elena Berenice Martínez-Shio  1 , Laura Sherell Marín-Jáuregui  1 , Alma Celeste Rodríguez-Ortega  1 , Lesly Marsol Doníz-Padilla  1 , Roberto González-Amaro  1 , Carlos David Escobedo-Uribe  2 , Adriana Elizabeth Monsiváis-Urenda  1
Affiliations

Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction

Elena Berenice Martínez-Shio et al. Clin Exp Immunol. .

Abstract

A high percentage of patients with acute coronary syndrome develop heart failure due to the ischemic event. Regulatory T (Treg) cells are lymphocytes with suppressive capacity that control the immune response and include the conventional CD4+ CD25hi Foxp3+ cells and the CD4+ CD25var CD69+ LAP+ Foxp3- IL-10+ cells. No human follow-up studies focus on Treg cells' behavior after infarction and their possible relationship with ventricular function as a sign of postischemic cardiac remodeling. This study aimed to analyze, by flow cytometry, the circulating levels of CD69+ Treg cells and CD4+ CD25hi Foxp3+ cells, their IL-10+ production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4+ CD25hi Foxp3+ cells and IL-10+ MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced 6 months post-AMI. Regarding the suppressive function of CD4+ CD25+ regulatory cells, they were dysfunctional at 3 and 6 months post-AMI. The frequency of CD69+ Treg cells was similar between patients with AMI at 72 hours postinfarction and the control groups. Moreover, the frequency of CD69+ Treg cells at 3 and 6 months postischemic event did not vary over time. Treg cells play a role in regulating inflammation after an AMI, and its function may be compromised in this pathology. This work is the first report to evaluate CD69+ Foxp3- Treg cells in AMI patients.

Keywords: CD69; acute myocardial infarction; inflammation; regulatory T cell.

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Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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