Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Nov 6;40(12):347.
doi: 10.1007/s12032-023-02195-3.

Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment

Affiliations
Review

Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment

Rakhi Yadav et al. Med Oncol. .

Abstract

Cervical cancer is a huge worldwide health burden, impacting women in impoverished nations in particular. Traditional therapeutic approaches, such as surgery, radiation therapy, and chemotherapy, frequently result in systemic toxicity and ineffectiveness. Nanomedicine has emerged as a viable strategy for targeted delivery of therapeutic drugs to cancer cells while decreasing off-target effects and increasing treatment success in recent years. Nanomedicine for cervical cancer introduces several novel aspects that distinguish it from previous treatment options such as tailored delivery system, precision targeting, combination therapies, real-time monitoring and diverse nanocarriers to overcome the limitations of one another. This abstract presents recent advances in nanomedicine-based tailored delivery systems for the treatment of cervical cancer. Liposomes, polymeric nanoparticles, dendrimers, and carbon nanotubes have all been intensively studied for their ability to transport chemotherapeutic medicines, nucleic acids, and imaging agents to cervical cancer cells. Because of the way these nanocarriers are designed, they may cross biological barriers and preferentially aggregate at the tumor site, boosting medicine concentration and lowering negative effects on healthy tissues. Surface modification of nanocarriers with targeting ligands like antibodies, peptides, or aptamers improves specificity for cancer cells by identifying overexpressed receptors or antigens on the tumor surface. Furthermore, nanomedicine-based techniques have made it possible to co-deliver numerous therapeutic drugs, allowing for synergistic effects and overcoming drug resistance. In preclinical and clinical investigations, combination treatments comprising chemotherapeutic medicines, gene therapy, immunotherapy, and photodynamic therapy have showed encouraging results, opening up new avenues for individualized and multimodal treatment regimens. Furthermore, the inclusion of contrast agents and imaging probes into nanocarrier systems has enabled real-time monitoring and imaging of treatment response. This enables the assessment of therapy efficacy, the early diagnosis of recurrence, and the optimization of treatment regimens.

Keywords: Angiogenesis; Cervical cancer; Immunotherapy; Nanomedicine; Oncoproteins; Pathophysiology; Tumor suppressor genes.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Kumar A, Yadav AK, Mishra V, Kumar D. Recent advancements in Triazole-b ased click chemistry in cancer drug discovery and development. SynOpen. 2023;7:186–208.
    1. Kumar A, Vigato C, Boschi D, Lolli ML, Kumar D. Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies. Eur J Med Chem. 2023;254: 115337. - PubMed
    1. Sharma A, Shambhwani D, Pandey S, Singh J, Lalhlenmawia H, Kumarasamy M, Singh SK, Chellappan DK, Gupta G, Prasher P, Dua K, Kumar D. Advances in lung cancer treatment using nanomedicines. ACS Omega. 2022;8:10–41. - PubMed - PMC
    1. Kumar S, Shukla MK, Sharma AK, Jayaprakash GK, Tonk RK, Chellappan DK, Singh SK, Dua K, Ahmed F, Bhattacharyya S, Kumar D. Metal-based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy. Medcomm. 2023;4: e253. - PubMed - PMC
    1. Shukla MK, Das AK, Gaurav A, Bisht D, Singh A, Kumar D (2023) Recent plant-based nanomedicine and nanocarrier for cancer treatment. In: Nanotechnology for drug delivery and pharmaceuticals, pp 187–206

Substances