Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment
- PMID: 37930458
- DOI: 10.1007/s12032-023-02195-3
Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment
Abstract
Cervical cancer is a huge worldwide health burden, impacting women in impoverished nations in particular. Traditional therapeutic approaches, such as surgery, radiation therapy, and chemotherapy, frequently result in systemic toxicity and ineffectiveness. Nanomedicine has emerged as a viable strategy for targeted delivery of therapeutic drugs to cancer cells while decreasing off-target effects and increasing treatment success in recent years. Nanomedicine for cervical cancer introduces several novel aspects that distinguish it from previous treatment options such as tailored delivery system, precision targeting, combination therapies, real-time monitoring and diverse nanocarriers to overcome the limitations of one another. This abstract presents recent advances in nanomedicine-based tailored delivery systems for the treatment of cervical cancer. Liposomes, polymeric nanoparticles, dendrimers, and carbon nanotubes have all been intensively studied for their ability to transport chemotherapeutic medicines, nucleic acids, and imaging agents to cervical cancer cells. Because of the way these nanocarriers are designed, they may cross biological barriers and preferentially aggregate at the tumor site, boosting medicine concentration and lowering negative effects on healthy tissues. Surface modification of nanocarriers with targeting ligands like antibodies, peptides, or aptamers improves specificity for cancer cells by identifying overexpressed receptors or antigens on the tumor surface. Furthermore, nanomedicine-based techniques have made it possible to co-deliver numerous therapeutic drugs, allowing for synergistic effects and overcoming drug resistance. In preclinical and clinical investigations, combination treatments comprising chemotherapeutic medicines, gene therapy, immunotherapy, and photodynamic therapy have showed encouraging results, opening up new avenues for individualized and multimodal treatment regimens. Furthermore, the inclusion of contrast agents and imaging probes into nanocarrier systems has enabled real-time monitoring and imaging of treatment response. This enables the assessment of therapy efficacy, the early diagnosis of recurrence, and the optimization of treatment regimens.
Keywords: Angiogenesis; Cervical cancer; Immunotherapy; Nanomedicine; Oncoproteins; Pathophysiology; Tumor suppressor genes.
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy.Eur J Pharm Biopharm. 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. Epub 2015 Mar 23. Eur J Pharm Biopharm. 2015. PMID: 25813885 Review.
-
Nanocellulose-based Delivery Systems and Cervical Cancer: Review of the Literature.Curr Pharm Des. 2021;27(46):4707-4715. doi: 10.2174/1381612827666210927110937. Curr Pharm Des. 2021. PMID: 34579625 Review.
-
Nanocarriers for the Effective Treatment of Cervical Cancer: Research Advancements and Patent Analysis.Recent Pat Drug Deliv Formul. 2018;12(2):93-109. doi: 10.2174/1872211312666180403102019. Recent Pat Drug Deliv Formul. 2018. PMID: 29611489 Review.
-
Advancement of cancer immunotherapy using nanoparticles-based nanomedicine.Semin Cancer Biol. 2022 Nov;86(Pt 2):624-644. doi: 10.1016/j.semcancer.2022.03.026. Epub 2022 Apr 1. Semin Cancer Biol. 2022. PMID: 35378274 Review.
-
Tumor-associated macrophages, nanomedicine and imaging: the axis of success in the future of cancer immunotherapy.Immunotherapy. 2017 Sep;9(10):819-835. doi: 10.2217/imt-2017-0041. Immunotherapy. 2017. PMID: 28877626 Review.
Cited by
-
(Nano)biotechnological approaches in the treatment of cervical cancer: integration of engineering and biology.Front Immunol. 2024 Sep 13;15:1461894. doi: 10.3389/fimmu.2024.1461894. eCollection 2024. Front Immunol. 2024. PMID: 39346915 Free PMC article. Review.
-
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation.Curr Top Med Chem. 2024;24(12):1050-1074. doi: 10.2174/0115680266282518231231075311. Curr Top Med Chem. 2024. PMID: 38279745 Review.
-
Stem cell technology for antitumor drug loading and delivery in oncology.Oncol Res. 2024 Feb 6;32(3):433-437. doi: 10.32604/or.2023.046497. eCollection 2024. Oncol Res. 2024. PMID: 38361752 Free PMC article. Review.
References
-
- Kumar A, Yadav AK, Mishra V, Kumar D. Recent advancements in Triazole-b ased click chemistry in cancer drug discovery and development. SynOpen. 2023;7:186–208.
-
- Kumar A, Vigato C, Boschi D, Lolli ML, Kumar D. Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies. Eur J Med Chem. 2023;254: 115337. - PubMed
-
- Shukla MK, Das AK, Gaurav A, Bisht D, Singh A, Kumar D (2023) Recent plant-based nanomedicine and nanocarrier for cancer treatment. In: Nanotechnology for drug delivery and pharmaceuticals, pp 187–206
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical