Risk of primary infection and reinfection with respiratory syncytial virus
- PMID: 3706232
- DOI: 10.1001/archpedi.1986.02140200053026
Risk of primary infection and reinfection with respiratory syncytial virus
Abstract
Respiratory syncytial virus is the most important cause of serious lower respiratory tract infection in children. For children followed up from birth in the Houston Family Study, the infection rate was 68.8/100 children less than 12 months of age and 82.6/100 during the second year of life. Virtually all children had been infected at least once by 24 months of age, and about one half had experienced two infections. Although lower respiratory tract disease (LRD) was common (22.4/100 during year 1 and 13.0/100 during year 2), most children had only one LRD illness. The risk of reinfection was inversely related to the level of neutralizing antibodies in the serum. Reinfection illnesses were generally mild, and risk of reinfection decreased to only 33.3/100 during year 4. Studies of children with LRD and surveys of hospitalizations provide the basis for an estimate of the number of children hospitalized each year during the respiratory syncytial virus epidemics. Almost 100,000 children in the United States experience an illness of sufficient severity to require hospitalization.
Similar articles
-
Influenza in children. Relationship to other respiratory agents.JAMA. 1980 Apr 4;243(13):1345-9. doi: 10.1001/jama.243.13.1345. JAMA. 1980. PMID: 6244421
-
Respiratory syncytial virus infection in children with bronchopulmonary dysplasia.Pediatrics. 1988 Aug;82(2):199-203. Pediatrics. 1988. PMID: 3399292
-
The Seattle Virus Watch. VI. Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses and Mycoplasma pneumoniae.Am J Epidemiol. 1975 Jun;101(6):532-51. doi: 10.1093/oxfordjournals.aje.a112125. Am J Epidemiol. 1975. PMID: 168766
-
Pulmonary infections with respiratory syncytial virus and the parainfluenza viruses.Semin Respir Infect. 1987 Jun;2(2):112-21. Semin Respir Infect. 1987. PMID: 2827280 Review.
-
Detection, pathogenesis, and therapy of respiratory syncytial virus infections.Clin Microbiol Rev. 1988 Jan;1(1):27-39. doi: 10.1128/CMR.1.1.27. Clin Microbiol Rev. 1988. PMID: 3060243 Free PMC article. Review.
Cited by
-
The incidence and clinical burden of respiratory syncytial virus disease identified through hospital outpatient presentations in Kenyan children.PLoS One. 2012;7(12):e52520. doi: 10.1371/journal.pone.0052520. Epub 2012 Dec 26. PLoS One. 2012. PMID: 23300695 Free PMC article.
-
What U.S. Obstetricians Need to Know About Respiratory Syncytial Virus.Obstet Gynecol. 2024 Mar 1;143(3):e54-e62. doi: 10.1097/AOG.0000000000005492. Epub 2023 Dec 7. Obstet Gynecol. 2024. PMID: 38061043 Free PMC article. Review.
-
Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age -- a systematic review and meta-analysis.Croat Med J. 2013 Apr;54(2):122-34. doi: 10.3325/cmj.2013.54.122. Croat Med J. 2013. PMID: 23630140 Free PMC article. Review.
-
Clinical characteristics and viral load of respiratory syncytial virus and human metapneumovirus in children hospitaled for acute lower respiratory tract infection.J Med Virol. 2017 Apr;89(4):589-597. doi: 10.1002/jmv.24687. Epub 2016 Sep 28. J Med Virol. 2017. PMID: 27632796 Free PMC article.
-
Comparative analysis of spatial-temporal patterns of human metapneumovirus and respiratory syncytial virus in Africa using genetic data, 2011-2014.Virol J. 2021 May 29;18(1):104. doi: 10.1186/s12985-021-01570-8. Virol J. 2021. PMID: 34051792 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Other Literature Sources