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Review
. 2021 Oct 20;9(4):63.
doi: 10.3390/medsci9040063.

Epidemiology of Melanoma

Kalyan Saginala  1 , Adam Barsouk  2 , John Sukumar Aluru  3 , Prashanth Rawla  4 , Alexander Barsouk  5
Affiliations
Review

Epidemiology of Melanoma

Kalyan Saginala et al. Med Sci (Basel). .

Abstract

Melanoma accounts for 1.7% of global cancer diagnoses and is the fifth most common cancer in the US. Melanoma incidence is rising in developed, predominantly fair-skinned countries, growing over 320% in the US since 1975. However, US mortality has fallen almost 30% over the past decade with the approval of 10 new targeted or immunotherapy agents since 2011. Mutations in the signaling-protein BRAF, present in half of cases, are targeted with oral BRAF/MEK inhibitor combinations, while checkpoint inhibitors are used to restore immunosurveillance likely inactivated by UV radiation. Although the overall 5-year survival has risen to 93.3% in the US, survival for stage IV disease remains only 29.8%. Melanoma is most common in white, older men, with an average age of diagnosis of 65. Outdoor UV exposure without protection is the main risk factor, although indoor tanning beds, immunosuppression, family history and rare congenital diseases, moles, and obesity contribute to the disease. Primary prevention initiatives in Australia implemented since 1988, such as education on sun-protection, have increased sun-screen usage and curbed melanoma incidence, which peaked in Australia in 2005. In the US, melanoma incidence is not projected to peak until 2022-2026. Fewer than 40% of Americans report practicing adequate protection (sun avoidance from 10 a.m.-4 p.m. and regular application of broad-spectrum sunscreen with an SPF > 30). A 2-4-fold return on investment is predicted for a US sun-protection education initiative. Lesion-directed skin screening programs, especially for those at risk, have also cost-efficiently reduced melanoma mortality.

Keywords: epidemiology; incidence; melanoma; mortality; prevention; risk factors.

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Conflict of interest statement

Alexander Barsouk served as a consultant for Bristol-Myers Squibb. The other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bar chart showing estimated age-standardized incidence and mortality rates (World) in 2020, melanoma of skin, all sexes, all ages. Data obtained from Globocan 2020 [5].
Figure 2
Figure 2
Map showing estimated age-standardized incidence rates (ASR) for melanoma of skin worldwide in 2020, all sexes, including all ages. Created with mapchart.net. Data obtained from Globocan 2020 [5].
Figure 3
Figure 3
Map showing estimated age-standardized mortality rates (ASR) for melanoma of skin worldwide in 2020, all sexes, including all ages. Created with mapchart.net. Data obtained from Globocan 2020 [5].
Figure 4
Figure 4
Melanoma of the skin 5-year SEER relative survival rates, 2011–2017 by stage at diagnosis and sex. Data source: US Mortality Files, National Center for Health Statistics, CDC [1].
See this image and copyright information in PMC

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References

    1. National Cancer Institute Melanoma of the Skin-Cancer Stat Facts. [(accessed on 10 May 2021)]; Available online: https://seer.cancer.gov/statfacts/html/melan.html.
    1. Rabbie R., Ferguson P., Molina-Aguilar C., Adams D.J., Robles-Espinoza C.D. Melanoma subtypes: Genomic profiles, prognostic molecular markers and therapeutic possibilities. J. Pathol. 2019;247:539–551. doi: 10.1002/path.5213. - DOI - PMC - PubMed
    1. Yang J., Manson D.K., Marr B.P., Carvajal R.D. Treatment of uveal melanoma: Where are we now? Ther. Adv. Med. Oncol. 2018;10:1758834018757175. doi: 10.1177/1758834018757175. - DOI - PMC - PubMed
    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Ferlay J., Ervik M., Lam F., Colombet M., Mery L., Piñeros M., Znaor A., Soerjomataram I., Bray F. International Agency for Research on Cancer; Lyon, France: [(accessed on 10 May 2021)]. Global Cancer Observatory: Cancer Today. Available online: https://gco.iarc.fr/today.

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