Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience

doi:10.1093/gerona/glab215

. 2022 Jan 7;77(1):e1-e9.

doi: 10.1093/gerona/glab215.

Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience

Abbi R Hernandez^{1

2

3}, Jessica M Hoffman⁴, Caesar M Hernandez⁵, Constanza J Cortes^{2

5

6

7}, Patricia Jumbo-Lucioni^{4

8}, Mark G Baxter⁹, Karyn A Esser¹⁰, Andrew C Liu¹⁰, Lori L McMahon^{2

5

6

11}, Jennifer L Bizon¹², Sara N Burke¹², Thomas W Buford^{1

2

6

11

13}, Christy S Carter^{1

2

6

11}

Affiliations

¹ Division of Gerontology, Geriatrics and Palliative Care, School of Medicine, University of Alabama at Birmingham, USA.
² UAB Center for Exercise Medicine, University of Alabama at Birmingham, USA.
³ Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham (UAB), USA.
⁴ Department of Biology, University of Alabama at Birmingham, USA.
⁵ Department of Cellular, Development, and Integrative Biology, School of Medicine, University of Alabama at Birmingham, USA.
⁶ UAB Nathan Shock Center for the Basic Biology of Aging, University of Alabama at Birmingham, USA.
⁷ Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, USA.
⁸ Pharmaceutical, Social, and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama,USA.
⁹ Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
¹⁰ Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA.
¹¹ UAB Integrative Center for Aging Research, University of Alabama at Birmingham, USA.
¹² Department of Neuroscience and Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, USA.
¹³ Geriatric Research Education and Clinical Center, Birmingham VA Medical Center, Birmingham, AL, USA.

PMID: 34309630
PMCID: PMC8751793
DOI: 10.1093/gerona/glab215

Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience

Abbi R Hernandez et al. J Gerontol A Biol Sci Med Sci. 2022.

. 2022 Jan 7;77(1):e1-e9.

doi: 10.1093/gerona/glab215.

Authors

Affiliations

¹ Division of Gerontology, Geriatrics and Palliative Care, School of Medicine, University of Alabama at Birmingham, USA.
² UAB Center for Exercise Medicine, University of Alabama at Birmingham, USA.
³ Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham (UAB), USA.
⁴ Department of Biology, University of Alabama at Birmingham, USA.
⁵ Department of Cellular, Development, and Integrative Biology, School of Medicine, University of Alabama at Birmingham, USA.
⁶ UAB Nathan Shock Center for the Basic Biology of Aging, University of Alabama at Birmingham, USA.
⁷ Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, USA.
⁸ Pharmaceutical, Social, and Administrative Sciences, McWhorter School of Pharmacy, Samford University, Birmingham, Alabama,USA.
⁹ Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
¹⁰ Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, USA.
¹¹ UAB Integrative Center for Aging Research, University of Alabama at Birmingham, USA.
¹² Department of Neuroscience and Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, USA.
¹³ Geriatric Research Education and Clinical Center, Birmingham VA Medical Center, Birmingham, AL, USA.

PMID: 34309630
PMCID: PMC8751793
DOI: 10.1093/gerona/glab215

No abstract available

Keywords: Brain aging; Cognitive decline; Metabolism; Muscles.

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Figures

**Figure 1.**
Proposed mechanisms through which collaborative efforts between geroscientists and neuroscientists will continue to propagate and enhance scientific gain. Enhanced training at the more junior levels will help to quickly actualize these concepts. Propagation at any level of the diagram will continue to have profound effects on the other elements, ultimately benefitting both fields.

See this image and copyright information in PMC

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Biological aging processes underlying cognitive decline and neurodegenerative disease.
Gonzales MM, Garbarino VR, Pollet E, Palavicini JP, Kellogg DL Jr, Kraig E, Orr ME. Gonzales MM, et al. J Clin Invest. 2022 May 16;132(10):e158453. doi: 10.1172/JCI158453. J Clin Invest. 2022. PMID: 35575089 Free PMC article. Review.
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Taha HB, Birnbaum A, Matthews I, Aceituno K, Leon J, Thorwald M, Godoy-Lugo J, Cortes CJ. Taha HB, et al. Geroscience. 2024 Sep 13. doi: 10.1007/s11357-024-01345-3. Online ahead of print. Geroscience. 2024. PMID: 39269584
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Irwansyah I. Irwansyah I. Geriatrics (Basel). 2022 Dec 26;8(1):3. doi: 10.3390/geriatrics8010003. Geriatrics (Basel). 2022. PMID: 36648908 Free PMC article.
A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging.
Hernandez CM, Hernandez AR, Hoffman JM, King PH, McMahon LL, Buford TW, Carter C, Bizon JL, Burke SN. Hernandez CM, et al. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):e19-e33. doi: 10.1093/gerona/glab301. J Gerontol A Biol Sci Med Sci. 2022. PMID: 34623396 Free PMC article.

References

1. Reserve & Resilience. Background/Need. https://reserveandresilience.com/background/#Background. Accessed July 19, 2021.
1. Stern Y, Arenaza‐Urquijo EM, Bartrés‐Faz D, et al. . Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020;16(9):1305–1311. doi:10.1016/j.jalz.2018.07.219 - DOI - PMC - PubMed
1. Kirkland JL, Stout MB, Sierra F. Resilience in aging mice. J Gerontol A Biol Sci Med Sci. 2016;71(11):1407–1414. doi:10.1093/gerona/glw086 - DOI - PMC - PubMed
1. Ukraintseva S, Arbeev K, Duan M, et al. . Decline in biological resilience as key manifestation of aging: potential mechanisms and role in health and longevity. Mech Ageing Dev. 2020. doi:10.1016/j.mad.2020.111418 - DOI - PMC - PubMed
1. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. National Diabetes Statistics Report. 2020. https://www.cdc.gov/diabetes/data/statistics-report/diagnosed-undiagnose.... Accessed November 2, 2020.

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[1] Reserve & Resilience. Background/Need. https://reserveandresilience.com/background/#Background. Accessed July 19, 2021.

[2] Reserve & Resilience. Background/Need. https://reserveandresilience.com/background/#Background. Accessed July 19, 2021.

[3] Stern Y, Arenaza‐Urquijo EM, Bartrés‐Faz D, et al. . Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020;16(9):1305–1311. doi:10.1016/j.jalz.2018.07.219 - DOI - PMC - PubMed

[4] Stern Y, Arenaza‐Urquijo EM, Bartrés‐Faz D, et al. . Whitepaper: defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020;16(9):1305–1311. doi:10.1016/j.jalz.2018.07.219 - DOI - PMC - PubMed

[5] Kirkland JL, Stout MB, Sierra F. Resilience in aging mice. J Gerontol A Biol Sci Med Sci. 2016;71(11):1407–1414. doi:10.1093/gerona/glw086 - DOI - PMC - PubMed

[6] Kirkland JL, Stout MB, Sierra F. Resilience in aging mice. J Gerontol A Biol Sci Med Sci. 2016;71(11):1407–1414. doi:10.1093/gerona/glw086 - DOI - PMC - PubMed

[7] Ukraintseva S, Arbeev K, Duan M, et al. . Decline in biological resilience as key manifestation of aging: potential mechanisms and role in health and longevity. Mech Ageing Dev. 2020. doi:10.1016/j.mad.2020.111418 - DOI - PMC - PubMed

[8] Ukraintseva S, Arbeev K, Duan M, et al. . Decline in biological resilience as key manifestation of aging: potential mechanisms and role in health and longevity. Mech Ageing Dev. 2020. doi:10.1016/j.mad.2020.111418 - DOI - PMC - PubMed

[9] Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. National Diabetes Statistics Report. 2020. https://www.cdc.gov/diabetes/data/statistics-report/diagnosed-undiagnose.... Accessed November 2, 2020.

[10] Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. National Diabetes Statistics Report. 2020. https://www.cdc.gov/diabetes/data/statistics-report/diagnosed-undiagnose.... Accessed November 2, 2020.

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Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience

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Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience

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