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Case Reports
. 2021 Jun;12(2):311-314.
doi: 10.1007/s13193-021-01335-3. Epub 2021 Apr 28.

Pseudovascular Adenoid Squamous Cell Carcinoma of Buccal Mucosa-a Rare Aggressive Variant

V Vivek  1   2 , Kunal Nandy  1 , Supreet Bhatt  1 , Rujuta Ankit Shah  3
Affiliations
Case Reports

Pseudovascular Adenoid Squamous Cell Carcinoma of Buccal Mucosa-a Rare Aggressive Variant

V Vivek et al. Indian J Surg Oncol. 2021 Jun.

Abstract

Pseudo-vascular adenoid squamous cell carcinoma (PASCC) is an uncommon histological variant. It is characterized by an acantholysis of the tumor cells and the formation of anastomosing spaces and channels. It gives a false appearance of glandular differentiation mimicking angiosarcoma. PASCC has been reported in the head and neck, as well as in other organs like the breast, lungs, urinary bladder, vulva, and the uterine cervix. We report a case of PASCC of the oral cavity in a recently operated case of squamous cell carcinoma of the buccal mucosa.

Keywords: Angiosarcoma; E-cadherin; Pseudo-vascular adenoid squamous cell carcinoma; Recurrence.

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Conflict of interest statement

Conflict of InterestThe authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The clinical picture of the patient showing a recurrent lesion on the left side of the face and neck with skin ulceration on postoperative day 35
Fig. 2
Fig. 2
Histopathology shows high-grade malignant cells arranged diffusely with the formation of pseudo-vascular and pseudo-glandular spaces; cells are highly pleomorphic showing hyperchromatic nucleus, prominent macronuclei, and a moderate amount of cytoplasm; brisk mitotic activity is evident. Increased vascularity hemorrhage; inflammation is evident
See this image and copyright information in PMC

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