Review
doi: 10.1016/j.jid.2020.12.011.
Epub 2021 Feb 1.
Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms
Affiliations
- PMID: 33541724
- DOI: 10.1016/j.jid.2020.12.011
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Review
Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms
J Invest Dermatol.
2021 Apr.
Free article
Abstract
As a barrier organ, the skin is an ideal model to study environmentally-induced (extrinsic) aging. In this review, we explain the development of extrinsic skin aging as a consequence of skin exposure to specific exposomal factors, their interaction with each other, and the modification of their effects on the skin by genetic factors. We also review the evidence that exposure to these exposomal factors causes extrinsic skin aging by mechanisms that critically involve the accumulation of macromolecular damage and the subsequent development of functionally altered and/or senescent fibroblasts in the dermal compartment of the skin.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
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