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Review
. 2020 Dec:65:162-166.
doi: 10.1016/j.conb.2020.10.008. Epub 2020 Dec 3.

The promise of the BRAIN initiative: NIH strategies for understanding neural circuit function

Nina S Hsu, Hsiao Yu Fang, Karen K David, James W Gnadt, Grace Cy Peng, Edmund M Talley, Jacqueline M Ward, John Ngai, Walter J Koroshetz
Free article
Review

The promise of the BRAIN initiative: NIH strategies for understanding neural circuit function

Nina S Hsu et al. Curr Opin Neurobiol. 2020 Dec.
Free article

Abstract

New neurotechnologies fueled by the BRAIN Initiative now allow investigators to map, monitor and modulate complex neural circuits, enabling the pursuit of research questions previously considered unapproachable. Yet it is the convergence of molecular neuroscience with the new systems neuroscience that promises the greatest future advances. This is particularly true for our understanding of nervous system disorders, some of which have known molecular drivers or pathology but result in unknown perturbations in circuit function. NIH-supported research on "BRAIN Circuits" programs integrate experimental, analytic, and theoretical capabilities for analysis of specific neural circuits and their contributions to perceptions, motivations, and actions. In this review, we describe the BRAIN priority areas, review our strategy for balancing early feasibility with mature projects, and the balance of individual with team science for this 'BRAIN Circuits' program. We also highlight the diverse portfolio of techniques, species, and neural systems represented in these projects.

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