Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone
- PMID: 3308166
- DOI: 10.1161/01.cir.76.4.827
Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone
Abstract
Coronary artery disease (CAD) has been shown in previous uncontrolled studies to be a limiting factor to long-term survival in patients undergoing cardiac transplantation and who were taking conventional immunosuppressive agents. To study the development of CAD after cardiac transplantation in patients taking the newer immunosuppressive agent cyclosporine, we prospectively performed yearly coronary arteriography on all eligible transplantation patients (first year, 57 patients; second year, 30 patients; third year, 14 patients). The prevalence of CAD by life table analysis was 18% at 1 year, 27% at 2 years, and 44% at 3 years. The occurrence of two or more major rejection episodes was associated (p less than .005) with the development of CAD. In two patients who died of CAD, coronary artery histology revealed subintimal inflammatory cellular infiltration in some lesions. These data demonstrate that the prevalence of CAD rises progressively over time and immunologic factors may be important in its development.
Similar articles
-
Prevalence of accelerated coronary artery disease in heart transplant survivors. Comparison of cyclosporine and azathioprine regimens.Circulation. 1989 Nov;80(5 Pt 2):III100-5. Circulation. 1989. PMID: 2805287
-
Decreasing incidence of coronary disease in pediatric cardiac transplant recipients using increased immunosuppression.Circulation. 1993 Nov;88(5 Pt 2):II224-9. Circulation. 1993. PMID: 8222158
-
Coronary artery disease in cardiac transplant patients receiving triple-drug immunosuppressive therapy.Circulation. 1989 Nov;80(5 Pt 2):III111-5. Circulation. 1989. PMID: 2805289
-
Accelerated graft coronary artery disease: diagnosis and prevention.J Heart Lung Transplant. 1992 Jul-Aug;11(4 Pt 2):S258-65. J Heart Lung Transplant. 1992. PMID: 1515448 Review.
-
Cardiac transplantation.Intensive Care Med. 1989;15(5):283-9. doi: 10.1007/BF00263862. Intensive Care Med. 1989. PMID: 2671079 Review.
Cited by
-
Upregulation of fibronectin synthesis by interleukin-1 beta in coronary artery smooth muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets.J Clin Invest. 1993 Oct;92(4):1850-8. doi: 10.1172/JCI116776. J Clin Invest. 1993. PMID: 8408637 Free PMC article.
-
Association between the degree of platelet-derived growth factor-A chain mRNA expression and coronary arteriosclerosis in the transplanted heart.Heart Vessels. 1998;13(1):24-9. doi: 10.1007/BF02750640. Heart Vessels. 1998. PMID: 9923562
-
Effects of aspirin, dipyridamole, and cod liver oil on accelerated myointimal proliferation in canine veno-arterial allografts.Ann Surg. 1988 Dec;208(6):746-54. doi: 10.1097/00000658-198812000-00013. Ann Surg. 1988. PMID: 3196097 Free PMC article.
-
Coronary occlusive disease and late graft failure after cardiac transplantation.Br Heart J. 1992 Sep;68(3):260-5. doi: 10.1136/hrt.68.9.260. Br Heart J. 1992. PMID: 1389755 Free PMC article.
-
When and why do heart transplant recipients die? A 7 year experience of 1068 cardiac transplants.Virchows Arch A Pathol Anat Histopathol. 1993;422(6):453-8. doi: 10.1007/BF01606453. Virchows Arch A Pathol Anat Histopathol. 1993. PMID: 8333149
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
