The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor

doi:10.1016/j.prp.2020.153226

Review

. 2020 Oct;216(10):153226.

doi: 10.1016/j.prp.2020.153226. Epub 2020 Sep 19.

The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor

Affiliations

¹ Student Research Committee, Tabriz University of Medical Sciences, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Medicine, Faculty of Cellular and Molecular Biology, University of Shiraz, Iran.
³ Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Medical, Faculty of Medical, University of Shahid Beheshti, Iran.
⁵ Department of Experimental Biomedicine, Dr. Vahid Vahedian Medical Diagnostic Laboratory Gorgan, Iran; Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Sari, Iran.
⁶ Department of Materials Enginnering, Islamic Azad University, Najafabad, Isfahan, Iran.
⁷ Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
⁸ Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Iran.
⁹ University La Sapienza, Department of Experimental Medicine, System Biology Group, Rome, Italy.
¹⁰ Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.
¹¹ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
¹² Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Rashidi@tbzmed.ac.ir.
¹³ Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: nourimd@yahoo.com.

PMID: 32987338
DOI: 10.1016/j.prp.2020.153226

Review

The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor

Nazila Fathi Maroufi et al. Pathol Res Pract. 2020 Oct.

. 2020 Oct;216(10):153226.

doi: 10.1016/j.prp.2020.153226. Epub 2020 Sep 19.

Authors

Affiliations

¹ Student Research Committee, Tabriz University of Medical Sciences, Iran; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Medicine, Faculty of Cellular and Molecular Biology, University of Shiraz, Iran.
³ Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Medical, Faculty of Medical, University of Shahid Beheshti, Iran.
⁵ Department of Experimental Biomedicine, Dr. Vahid Vahedian Medical Diagnostic Laboratory Gorgan, Iran; Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Sari, Iran.
⁶ Department of Materials Enginnering, Islamic Azad University, Najafabad, Isfahan, Iran.
⁷ Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
⁸ Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Iran.
⁹ University La Sapienza, Department of Experimental Medicine, System Biology Group, Rome, Italy.
¹⁰ Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands.
¹¹ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
¹² Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Rashidi@tbzmed.ac.ir.
¹³ Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: nourimd@yahoo.com.

PMID: 32987338
DOI: 10.1016/j.prp.2020.153226

Abstract

Breast cancer is the most common cancer among women and its metastasis which generally observed at the last stage is the major cause of breast cancer-related death. Therefore, the agents that have the potential to prevent metastatic and invasive nature of breast cancer can open up new therapeutic strategies. Melatonin, a major hormone of pineal gland, is a powerful anti-cancer agent. There are growing evidence regarding the protective effect of melatonin against cancer invasion and metastasis. The anti-metastatic feature of melatonin accompanies with suppression of tumor proliferation, induction of tumor apoptosis, regulation of the cell cycle, modulating angiogenesis, impediment of invasion, and induction of cancer cells sensitivity to the chemotherapy agents. More recently, anti-metastatic effect of melatonin through affecting cancer stem cells and vascular mimicry has been identified. Thus, the aim of this review is to discuss the potential therapeutic effect of melatonin on breast cancer via modulating the cells invasion and metastasis.

Keywords: Breast cancer; Cancer stem cells; Invasion; Melatonin; Metastasis; Vascular mimicry.

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The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor

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The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor

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