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. 1988 Nov 1;177(2):357-61.
doi: 10.1111/j.1432-1033.1988.tb14384.x.

Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat

J V Castell  1 , T Geiger, V Gross, T Andus, E Walter, T Hirano, T Kishimoto, P C Heinrich
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Free article

Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat

J V Castell et al. Eur J Biochem. .
Free article

Abstract

The plasma half-life of recombinant human interleukin-6 (rhIL-6) was determined in rats by measuring the disappearance of the biological activity as well as of the radioactivity of 125I-rhIL-6 from the circulation. The kinetics of clearance were biphasic. It consisted of a rapid initial disappearance corresponding to a half-life of 3 min, and of a second slow one corresponding to a half-life of about 55 min. By cellulose-acetate electrophoresis it was shown that rhIL-6 binds to a plasma protein resulting in a complex migrating in the beta-gamma region; 20 min after intravenous injection, about 80% of the 125I-rhIL-6 that had disappeared from the circulation was found in the liver. 125I-rhIL-6 was exclusively localized on the surface of parenchymal cells suggesting the existence of an interleukin-6 receptor on the hepatocytes.

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