Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

doi:10.1186/s13054-020-03046-7

. 2020 Jun 5;24(1):299.

doi: 10.1186/s13054-020-03046-7.

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Jie Wang¹, Qing Yang², Piaopiao Zhang², Jifang Sheng², Jianying Zhou¹, Tingting Qu^{3

4}

Affiliations

¹ Respiratory Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
² State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 79# Qingchun East Road, Hangzhou, 310001, Zhejiang, China.
³ State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 79# Qingchun East Road, Hangzhou, 310001, Zhejiang, China. qutingting@zju.edu.cn.
⁴ Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. qutingting@zju.edu.cn.

PMID: 32503617
PMCID: PMC7274513
DOI: 10.1186/s13054-020-03046-7

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Jie Wang et al. Crit Care. 2020.

. 2020 Jun 5;24(1):299.

doi: 10.1186/s13054-020-03046-7.

Authors

Jie Wang¹, Qing Yang², Piaopiao Zhang², Jifang Sheng², Jianying Zhou¹, Tingting Qu^{3

4}

Affiliations

¹ Respiratory Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
² State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 79# Qingchun East Road, Hangzhou, 310001, Zhejiang, China.
³ State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, 79# Qingchun East Road, Hangzhou, 310001, Zhejiang, China. qutingting@zju.edu.cn.
⁴ Infection Control Department, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. qutingting@zju.edu.cn.

PMID: 32503617
PMCID: PMC7274513
DOI: 10.1186/s13054-020-03046-7

No abstract available

Keywords: Bronchoscopy; COVID-19; Invasive pulmonary aspergillosis; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

**Fig. 1**
Lung CT scans and bronchoscopy findings of patients with COVID-2019 and IPA. Patient 1, 90 years, lung CT scan showed nodules with cavities in the middle lobe of the right lung and consolidation bilateral lower lobes with a small amount of pleural effusion (a); bronchoscopy finding showed small ulcer in the right wall of the trachea (c). Patient 2, 74 years, lung CT scan showed consolidation bilateral lower lobes with multiple irregular cavities in the middle (b); bronchoscopy finding showed right middle bronchial ulcer (d). Red arrow indicated the positions of bronchial ulcers

See this image and copyright information in PMC

Comment in

No time for pending confirmation of invasive fungal disease in critically ill COVID-19 patients-think empirical treatment.
Bienvenu AL, Bleyzac N, Richard JC, Leboucher G. Bienvenu AL, et al. Crit Care. 2020 Sep 29;24(1):588. doi: 10.1186/s13054-020-03307-5. Crit Care. 2020. PMID: 32993759 Free PMC article. No abstract available.

Cited by

COVID-19 associated with pulmonary aspergillosis: A literature review.
Lai CC, Yu WL. Lai CC, et al. J Microbiol Immunol Infect. 2021 Feb;54(1):46-53. doi: 10.1016/j.jmii.2020.09.004. Epub 2020 Sep 24. J Microbiol Immunol Infect. 2021. PMID: 33012653 Free PMC article. Review.
Incidence and mortality of COVID-19-associated pulmonary aspergillosis: A systematic review and meta-analysis.
Mitaka H, Kuno T, Takagi H, Patrawalla P. Mitaka H, et al. Mycoses. 2021 Sep;64(9):993-1001. doi: 10.1111/myc.13292. Epub 2021 May 6. Mycoses. 2021. PMID: 33896063 Free PMC article.
A comprehensive review of adverse events to drugs used in COVID-19 patients: Recent clinical evidence.
Ferreira-da-Silva R, Ribeiro-Vaz I, Morato M, Junqueira Polónia J. Ferreira-da-Silva R, et al. Eur J Clin Invest. 2022 Jul;52(7):e13763. doi: 10.1111/eci.13763. Epub 2022 Feb 27. Eur J Clin Invest. 2022. PMID: 35224719 Free PMC article. Review.
COVID-19-Associated Pulmonary Aspergillosis (CAPA).
Dimopoulos G, Almyroudi MP, Myrianthefs P, Rello J. Dimopoulos G, et al. J Intensive Med. 2021 Aug 7;1(2):71-80. doi: 10.1016/j.jointm.2021.07.001. eCollection 2021 Oct. J Intensive Med. 2021. PMID: 36785564 Free PMC article. Review.
Practice Guidelines for the Diagnosis of COVID-19-Associated Pulmonary Aspergillosis in an Intensive Care Setting.
Hashim Z, Neyaz Z, Marak RSK, Nath A, Nityanand S, Tripathy NK. Hashim Z, et al. J Intensive Care Med. 2022 Aug;37(8):985-997. doi: 10.1177/08850666211047166. Epub 2021 Oct 22. J Intensive Care Med. 2022. PMID: 34678103 Free PMC article. Review.

See all "Cited by" articles

References

1. Swiss Society Of Intensive Care M Recommendations for the admission of patients with COVID-19 to intensive care and intermediate care units (ICUs and IMCUs) Swiss Med Wkly. 2020;150:w20227. - PubMed
1. Liew MF, Siow WT, MacLaren G, See KC. Preparing for COVID-19: early experience from an intensive care unit in Singapore. Crit Care. 2020;24(1):83. doi: 10.1186/s13054-020-2814-x. - DOI - PMC - PubMed
1. Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2019. (Epub ahead of print). - PMC - PubMed
1. Schauwvlieghe A, Rijnders BJA, Philips N, Verwijs R, Vanderbeke L, Van Tienen C, Lagrou K, Verweij PE, Van de Veerdonk FL, Gommers D, et al. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018;6(10):782–792. doi: 10.1016/S2213-2600(18)30274-1. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

2018KY382/Zhejiang Province Medical and Health Science and Technology Project/International

LinkOut - more resources

Full Text Sources
Miscellaneous
- NCI CPTAC Assay Portal

[1] Swiss Society Of Intensive Care M Recommendations for the admission of patients with COVID-19 to intensive care and intermediate care units (ICUs and IMCUs) Swiss Med Wkly. 2020;150:w20227. - PubMed

[2] Swiss Society Of Intensive Care M Recommendations for the admission of patients with COVID-19 to intensive care and intermediate care units (ICUs and IMCUs) Swiss Med Wkly. 2020;150:w20227. - PubMed

[3] Liew MF, Siow WT, MacLaren G, See KC. Preparing for COVID-19: early experience from an intensive care unit in Singapore. Crit Care. 2020;24(1):83. doi: 10.1186/s13054-020-2814-x. - DOI - PMC - PubMed

[4] Liew MF, Siow WT, MacLaren G, See KC. Preparing for COVID-19: early experience from an intensive care unit in Singapore. Crit Care. 2020;24(1):83. doi: 10.1186/s13054-020-2814-x. - DOI - PMC - PubMed

[5] Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2019. (Epub ahead of print). - PMC - PubMed

[6] Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2019. (Epub ahead of print). - PMC - PubMed

[7] Schauwvlieghe A, Rijnders BJA, Philips N, Verwijs R, Vanderbeke L, Van Tienen C, Lagrou K, Verweij PE, Van de Veerdonk FL, Gommers D, et al. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018;6(10):782–792. doi: 10.1016/S2213-2600(18)30274-1. - DOI - PubMed

[8] Schauwvlieghe A, Rijnders BJA, Philips N, Verwijs R, Vanderbeke L, Van Tienen C, Lagrou K, Verweij PE, Van de Veerdonk FL, Gommers D, et al. Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study. Lancet Respir Med. 2018;6(10):782–792. doi: 10.1016/S2213-2600(18)30274-1. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Affiliations

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Authors

Affiliations

Conflict of interest statement

Figures

Comment in

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous