Obesity and Alzheimer's disease: Molecular bases

doi:10.1111/ejn.14758

Review

. 2020 Oct;52(8):3944-3950.

doi: 10.1111/ejn.14758. Epub 2020 May 23.

Obesity and Alzheimer's disease: Molecular bases

Pasquale Picone¹, Marta Di Carlo¹, Domenico Nuzzo¹

Affiliations

PMID: 32323378
DOI: 10.1111/ejn.14758

Review

Obesity and Alzheimer's disease: Molecular bases

Pasquale Picone et al. Eur J Neurosci. 2020 Oct.

. 2020 Oct;52(8):3944-3950.

doi: 10.1111/ejn.14758. Epub 2020 May 23.

Authors

Pasquale Picone¹, Marta Di Carlo¹, Domenico Nuzzo¹

Affiliation

¹ Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica (CNR-IRIB), Palermo, Italy.

PMID: 32323378
DOI: 10.1111/ejn.14758

Abstract

Obesity is a complex, chronic, and multifactorial condition characterized by abnormal fat accumulation in tissues and organs and inducing negative effects on human health. Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with amyloid plaques and neurofibrillary tangles in the brain. The correlation between obesity and Alzheimer's disease has been discovered, but the molecules and molecular mechanisms linking these conditions are not yet fully elucidated. In this review, we focused on the most important processes linking the fat accumulation and the alterations of the brain structure and functions.

Keywords: Alzheimer's disease; molecular mechanisms; obesity.

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References

REFERENCES

1. Anstey, K. J., Cherbuin, N., Budge, M., & Young, J. (2011). Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies. Obesity Reviews, 12, e426-e437. https://doi.org/10.1111/j.1467-789X.2010.00825.x
1. Arnold, S. E., Lucki, I., Brookshire, B. R., Carlson, G. C., Browne, C. A., Kazi, H., … McMullen, M. F. (2014). High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease, 67, 79-87. https://doi.org/10.1016/j.nbd.2014.03.011
1. Banks, W. A. (2001). Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity. Current Pharmaceutical Design, 7, 125-133. https://doi.org/10.2174/1381612013398310
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1. Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Alzheimer's & Dementia, 12, 719-732. https://doi.org/10.1016/j.jalz.2016.02.010

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[1] Anstey, K. J., Cherbuin, N., Budge, M., & Young, J. (2011). Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies. Obesity Reviews, 12, e426-e437. https://doi.org/10.1111/j.1467-789X.2010.00825.x

[2] Anstey, K. J., Cherbuin, N., Budge, M., & Young, J. (2011). Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies. Obesity Reviews, 12, e426-e437. https://doi.org/10.1111/j.1467-789X.2010.00825.x

[3] Arnold, S. E., Lucki, I., Brookshire, B. R., Carlson, G. C., Browne, C. A., Kazi, H., … McMullen, M. F. (2014). High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease, 67, 79-87. https://doi.org/10.1016/j.nbd.2014.03.011

[4] Arnold, S. E., Lucki, I., Brookshire, B. R., Carlson, G. C., Browne, C. A., Kazi, H., … McMullen, M. F. (2014). High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease, 67, 79-87. https://doi.org/10.1016/j.nbd.2014.03.011

[5] Banks, W. A. (2001). Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity. Current Pharmaceutical Design, 7, 125-133. https://doi.org/10.2174/1381612013398310

[6] Banks, W. A. (2001). Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity. Current Pharmaceutical Design, 7, 125-133. https://doi.org/10.2174/1381612013398310

[7] Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1995). Passage of cytokines across the blood-brain barrier. NeuroImmunoModulation, 2, 241-248.

[8] Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1995). Passage of cytokines across the blood-brain barrier. NeuroImmunoModulation, 2, 241-248.

[9] Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Alzheimer's & Dementia, 12, 719-732. https://doi.org/10.1016/j.jalz.2016.02.010

[10] Calsolaro, V., & Edison, P. (2016). Neuroinflammation in Alzheimer's disease: Current evidence and future directions. Alzheimer's & Dementia, 12, 719-732. https://doi.org/10.1016/j.jalz.2016.02.010

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Obesity and Alzheimer's disease: Molecular bases

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Obesity and Alzheimer's disease: Molecular bases

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