Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

doi:10.1001/jama.2020.4621

Case Reports

. 2020 May 12;323(18):1846-1848.

doi: 10.1001/jama.2020.4621.

Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

Lan Dong¹, Jinhua Tian¹, Songming He¹, Chuchao Zhu², Jian Wang³, Chen Liu³, Jing Yang¹

Affiliations

¹ Department of Obstetrics & Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
² Department of Obstetrics and Gynecology, General Hospital of Central Command Theater in PLA, Wuhan, Hubei, China.
³ Department of Radiology, First Affiliated Hospital to Army Medical University, Chongqing, China.

PMID: 32215581
PMCID: PMC7099527
DOI: 10.1001/jama.2020.4621

Case Reports

Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

Lan Dong et al. JAMA. 2020.

. 2020 May 12;323(18):1846-1848.

doi: 10.1001/jama.2020.4621.

Authors

Lan Dong¹, Jinhua Tian¹, Songming He¹, Chuchao Zhu², Jian Wang³, Chen Liu³, Jing Yang¹

Affiliations

¹ Department of Obstetrics & Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
² Department of Obstetrics and Gynecology, General Hospital of Central Command Theater in PLA, Wuhan, Hubei, China.
³ Department of Radiology, First Affiliated Hospital to Army Medical University, Chongqing, China.

PMID: 32215581
PMCID: PMC7099527
DOI: 10.1001/jama.2020.4621

Abstract

This case report describes birth of an infant with elevated anti–SARS-CoV-2 IgM antibodies and cytokine levels to a mother with polymerase chain reaction–confirmed coronavirus disease 2019 (COVID-19) despite no physical contact.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Comment in

Can SARS-CoV-2 Infection Be Acquired In Utero?: More Definitive Evidence Is Needed.
Kimberlin DW, Stagno S. Kimberlin DW, et al. JAMA. 2020 May 12;323(18):1788-1789. doi: 10.1001/jama.2020.4868. JAMA. 2020. PMID: 32215579 No abstract available.

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References

1. Wang W, Xu Y, Gao R, et al. . Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. Published March 11, 2020. doi:10.1001/jama.2020.3786 - DOI - PMC - PubMed
1. Woo PC, Lau SK, Wong BH, et al. . Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J Clin Microbiol. 2004;42(5):2306-2309. doi:10.1128/JCM.42.5.2306-2309.2004 - DOI - PMC - PubMed
1. Xu W, Li J, He X, et al. . The diagnostic value of joint detection of serum IgM and IgG antibodies to 2019-nCoV in 2019-nCoV infection. Chinese J Lab Med. 2020;43(00):E012-E012. doi:10.3760/cma.j.cn114452-20200223-00109 - DOI
1. Chen H, Guo J, Wang C, et al. . Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3 - DOI - PMC - PubMed

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[1] Wang W, Xu Y, Gao R, et al. . Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. Published March 11, 2020. doi:10.1001/jama.2020.3786 - DOI - PMC - PubMed

[2] Wang W, Xu Y, Gao R, et al. . Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. Published March 11, 2020. doi:10.1001/jama.2020.3786 - DOI - PMC - PubMed

[3] Woo PC, Lau SK, Wong BH, et al. . Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J Clin Microbiol. 2004;42(5):2306-2309. doi:10.1128/JCM.42.5.2306-2309.2004 - DOI - PMC - PubMed

[4] Woo PC, Lau SK, Wong BH, et al. . Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J Clin Microbiol. 2004;42(5):2306-2309. doi:10.1128/JCM.42.5.2306-2309.2004 - DOI - PMC - PubMed

[5] Xu W, Li J, He X, et al. . The diagnostic value of joint detection of serum IgM and IgG antibodies to 2019-nCoV in 2019-nCoV infection. Chinese J Lab Med. 2020;43(00):E012-E012. doi:10.3760/cma.j.cn114452-20200223-00109 - DOI

[6] Xu W, Li J, He X, et al. . The diagnostic value of joint detection of serum IgM and IgG antibodies to 2019-nCoV in 2019-nCoV infection. Chinese J Lab Med. 2020;43(00):E012-E012. doi:10.3760/cma.j.cn114452-20200223-00109 - DOI

[7] Chen H, Guo J, Wang C, et al. . Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3 - DOI - PMC - PubMed

[8] Chen H, Guo J, Wang C, et al. . Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395(10226):809-815. doi:10.1016/S0140-6736(20)30360-3 - DOI - PMC - PubMed

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Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

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Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

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