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Clinical Trial
. 2020 Jan;81(1):26-31.
doi: 10.1016/j.humimm.2019.11.007. Epub 2019 Dec 19.

Association of IL-6, IL-10 and CXCL10 serum concentrations with visceral Kaposi's sarcoma in people living with HIV/AIDS

Thaísa Regina Rocha Lopes  1 , Juliana Prado Gonçales  1 , José Valter Joaquim Silva Júnior  2 , Virginia Maria Barros de Lorena  3 , Ana Luiza Castro Conde Toscano  4 , Sandra Mitie Akamatsu  4 , Angela Christina Salles  4 , Tania Regina Tozetto-Mendoza  5 , Viviane Martha Santos de Morais  1 , Maria Rosângela Cunha Duarte Coêlho  6
Affiliations
Clinical Trial

Association of IL-6, IL-10 and CXCL10 serum concentrations with visceral Kaposi's sarcoma in people living with HIV/AIDS

Thaísa Regina Rocha Lopes et al. Hum Immunol. 2020 Jan.

Abstract

Human gammaherpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS), one of the most common cancers in people living with HIV/AIDS. It is believe that the course of both HIV and HHV-8 infection is associated with the imbalance of anti- and/or pro-inflammatory cytokines. Here, we evaluated the IL-6, TNF-α, IL-10, CCL2 and CXCL10 serum concentrations in HIV- and HIV/HHV-8 (without KS) individuals, and in patients with cutaneous or visceral AIDS-KS. Serum concentrations of IL-6, IL-10 and CXCL10 were significantly higher in the AIDS-KS group compared to HIV and HIV/HHV-8 individuals. Similarly, the concentrations of theses cytokines were higher in patients with visceral than in those with cutaneous AIDS-KS. The TNF-α concentration was significantly higher in the HIV group compared to HIV/HHV-8 (with and without KS) individuals, and CCL2 levels did not present significant difference among the groups. The HIV viral load was undetectable in all patients from the HIV and HIV/HHV-8 groups. On the other hand, in the AIDS-KS group, most patients had detectable HIV viral load. In this context, we believe that the cytokine levels in AIDS-KS may be result of a complex interaction between HIV, HHV-8 and immunity.

Keywords: AIDS-KS; HHV-8; HIV/AIDS; Kaposi’s sarcoma; Pathogenesis.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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