Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

doi:10.1002/adma.201904040

Review

. 2020 May;32(18):e1904040.

doi: 10.1002/adma.201904040. Epub 2019 Sep 18.

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

Phuong H L Tran¹, Dongxi Xiang², Thao T D Tran^{3

4}, Wang Yin¹, Yumei Zhang¹, Lingxue Kong⁵, Kuisheng Chen⁶, Miaomiao Sun⁶, Yong Li⁷, Yingchun Hou⁸, Yimin Zhu⁹, Wei Duan^{1

10

11}

Affiliations

¹ School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, 3216, Australia.
² Division of Genetics, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 77 Avenue Louise Pasteur, Boston, MA, 02115, USA.
³ Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁴ Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁵ Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3216, Australia.
⁶ Department of Pathology, The First Affiliated Hospital, Zhengzhou University, He'nan Key Laboratory of Tumor Pathology, Zhengzhou, 450052, China.
⁷ Cancer Care Centre, St George Hospital, Kogarah, and St George and Sutherland Clinical School, University of New South Wales, Kensington, NSW, 2217, Australia.
⁸ Laboratory of Tumor Molecular and Cellular Biology, College of Life Sciences, Shaanxi Normal University, 620 West Chang'an Avenue, Xi'an, Shaanxi, 710119, China.
⁹ CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
¹⁰ GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Suzhou, 215123, China.
¹¹ GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Waurn Ponds, Victoria, 3216, Australia.

PMID: 31531916
DOI: 10.1002/adma.201904040

Review

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

Phuong H L Tran et al. Adv Mater. 2020 May.

. 2020 May;32(18):e1904040.

doi: 10.1002/adma.201904040. Epub 2019 Sep 18.

Authors

Phuong H L Tran¹, Dongxi Xiang², Thao T D Tran^{3

4}, Wang Yin¹, Yumei Zhang¹, Lingxue Kong⁵, Kuisheng Chen⁶, Miaomiao Sun⁶, Yong Li⁷, Yingchun Hou⁸, Yimin Zhu⁹, Wei Duan^{1

10

11}

Affiliations

¹ School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria, 3216, Australia.
² Division of Genetics, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 77 Avenue Louise Pasteur, Boston, MA, 02115, USA.
³ Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁴ Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
⁵ Institute for Frontier Materials, Deakin University, Geelong, Victoria, 3216, Australia.
⁶ Department of Pathology, The First Affiliated Hospital, Zhengzhou University, He'nan Key Laboratory of Tumor Pathology, Zhengzhou, 450052, China.
⁷ Cancer Care Centre, St George Hospital, Kogarah, and St George and Sutherland Clinical School, University of New South Wales, Kensington, NSW, 2217, Australia.
⁸ Laboratory of Tumor Molecular and Cellular Biology, College of Life Sciences, Shaanxi Normal University, 620 West Chang'an Avenue, Xi'an, Shaanxi, 710119, China.
⁹ CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
¹⁰ GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Suzhou, 215123, China.
¹¹ GenePharma-Deakin Joint Laboratory of Aptamer Medicine, Waurn Ponds, Victoria, 3216, Australia.

PMID: 31531916
DOI: 10.1002/adma.201904040

Abstract

Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50-150 nm nanovesicles that play important roles in cell-to-cell and/or cell-to-tissue communications and cross-species communication. Exosomes are also a promising class of novel drug delivery vehicles owing to their ability to shield their payload from chemical and enzymatic degradations as well as to evade recognition by and subsequent removal by the immune system. Combined with a new class of affinity ligands known as aptamers or chemical antibodies, molecularly targeted exosomes are poised to become the next generation of smartly engineered nanovesicles for precision medicine. Here, recent advances in targeted exosomal delivery systems engineered by aptamer for future strategies to promote human health using this class of human-derived nanovesicles are summarized.

Keywords: aptamers; exosomes; nanoengineering; precision therapeutics; targeting ligands.

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[8] B. Escudier, T. Dorval, N. Chaput, F. André, M.-P. Caby, S. Novault, C. Flament, C. Leboulaire, C. Borg, S. Amigorena, C. Boccaccio, C. Bonnerot, O. Dhellin, M. Movassagh, S. Piperno, C. Robert, V. Serra, N. Valente, J.-B. Le Pecq, A. Spatz, O. Lantz, T. Tursz, E. Angevin, L. Zitvogel, J. Transl. Med. 2005, 3, 10.

[9] L. Song, S. Tang, X. Han, Z. Jiang, L. Dong, C. Liu, X. Liang, J. Dong, C. Qiu, Y. Wang, Y. Du, Nat. Commun. 2019, 10, 1639.

[10] L. Song, S. Tang, X. Han, Z. Jiang, L. Dong, C. Liu, X. Liang, J. Dong, C. Qiu, Y. Wang, Y. Du, Nat. Commun. 2019, 10, 1639.

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Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

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Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

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