Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play A Role?

doi:10.3390/ijms20122922

Review

. 2019 Jun 14;20(12):2922.

doi: 10.3390/ijms20122922.

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play A Role?

Francesca Cirillo¹, Cecilia Catellani², Chiara Sartori³, Pietro Lazzeroni⁴, Sergio Amarri, Maria Elisabeth Street

Affiliations

¹ Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. francesca.cirillo@ausl.re.it.
² Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. cecilia.catellani@ausl.re.it.
³ Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. chiara.sartori@ausl.re.it.
⁴ These authors contributed equally to this work.. pietro.lazzaroni@ausl.re.it.

PMID: 31207998
PMCID: PMC6628223
DOI: 10.3390/ijms20122922

Review

Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play A Role?

Francesca Cirillo et al. Int J Mol Sci. 2019.

. 2019 Jun 14;20(12):2922.

doi: 10.3390/ijms20122922.

Authors

Francesca Cirillo¹, Cecilia Catellani², Chiara Sartori³, Pietro Lazzeroni⁴, Sergio Amarri, Maria Elisabeth Street

Affiliations

¹ Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. francesca.cirillo@ausl.re.it.
² Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. cecilia.catellani@ausl.re.it.
³ Department of Mother and Child, 42123 Azienda USL-IRCCS di Reggio Emilia, Italy. chiara.sartori@ausl.re.it.
⁴ These authors contributed equally to this work.. pietro.lazzaroni@ausl.re.it.

PMID: 31207998
PMCID: PMC6628223
DOI: 10.3390/ijms20122922

Abstract

Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with diseases including obesity and cancer. Herein we report dysregulated miRNAs in obesity both in animal models and in humans, and we also document dysregulated miRNAs in colorectal cancer (CRC), as example of an obesity-related cancer. Some of the described miRNAs are found to be similarly dysregulated both in obesity, insulin resistance (IR), and CRC. Thus, we present miRNAs as a potential molecular link between obesity and CRC onset and development, giving a new perspective on the role of miRNAs in obesity-associated cancers.

Keywords: cancer; colorectal cancer; inflammation; insulin resistance; microRNA; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Dysregulated microRNAs in common between obesity and colorectal cancer (CRC), possibly linking the two conditions.

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References

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[1] Stolarczyk E. Adipose tissue inflammation in obesity: A metabolic or immune response? Opin. Pharmacol. 2017;37:35–40. doi: 10.1016/j.coph.2017.08.006. - DOI - PubMed

[2] Stolarczyk E. Adipose tissue inflammation in obesity: A metabolic or immune response? Opin. Pharmacol. 2017;37:35–40. doi: 10.1016/j.coph.2017.08.006. - DOI - PubMed

[3] Liu Y., Han Z.P., Zhang S.S., Jing Y.Y., Bu X.X., Wang C.Y., Sun K., Jiang G.C., Zhao X., Li R., et al. Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J. Biol. Chem. 2011;286:25007–25015. doi: 10.1074/jbc.M110.213108. - DOI - PMC - PubMed

[4] Liu Y., Han Z.P., Zhang S.S., Jing Y.Y., Bu X.X., Wang C.Y., Sun K., Jiang G.C., Zhao X., Li R., et al. Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J. Biol. Chem. 2011;286:25007–25015. doi: 10.1074/jbc.M110.213108. - DOI - PMC - PubMed

[5] Cohen D.H., LeRoith D. Obesity, type 2 diabetes, and cancer: The insulin and IGF connection. Endocr. Relat. Cancer. 2012;19:F27–F45. doi: 10.1530/ERC-11-0374. - DOI - PubMed

[6] Cohen D.H., LeRoith D. Obesity, type 2 diabetes, and cancer: The insulin and IGF connection. Endocr. Relat. Cancer. 2012;19:F27–F45. doi: 10.1530/ERC-11-0374. - DOI - PubMed

[7] Lebovitz H.E. Insulin resistance: Definition and consequences. Exp. Clin. Endocrinol. Diabetes. 2001;109:S135–S148. doi: 10.1055/s-2001-18576. - DOI - PubMed

[8] Lebovitz H.E. Insulin resistance: Definition and consequences. Exp. Clin. Endocrinol. Diabetes. 2001;109:S135–S148. doi: 10.1055/s-2001-18576. - DOI - PubMed

[9] Shanmugalingam T., Bosco C., Ridley A.J., Van Hemelrijck M. Is there a role for IGF-1 in the development of second primary cancers? Cancer Med. 2016;5:3353–3367. doi: 10.1002/cam4.871. - DOI - PMC - PubMed

[10] Shanmugalingam T., Bosco C., Ridley A.J., Van Hemelrijck M. Is there a role for IGF-1 in the development of second primary cancers? Cancer Med. 2016;5:3353–3367. doi: 10.1002/cam4.871. - DOI - PMC - PubMed

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Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play A Role?

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Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play A Role?

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