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. 1988 Sep 30;241(4874):1815-7.
doi: 10.1126/science.3051377.

Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life

F H Claas  1 , Y Gijbels, J van der Velden-de Munck, J J van Rood
Affiliations

Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life

F H Claas et al. Science. .

Abstract

Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.

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