CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors
- PMID: 30504420
- DOI: 10.4049/jimmunol.1701153
CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors
Abstract
Innate lymphoid cells (ILCs) guard epithelial tissue integrity during homeostasis, but can be potent immune effector cells during inflammation. Precursors to all ILC subsets (ILC precursors [ILCP]) have been identified in human peripheral blood (PB). We found that during homeostasis, ILCP in PB of mouse and human expressed homing receptors for secondary lymphoid organs, mainly CD62L. These ILCP entered mouse lymph nodes in a CD62L-dependent way and relied on S1P receptors for their exit. Importantly, CD62L expression was absent on human ILCs expressing NKp44 in tonsils and PB of Crohn disease patients, and relatively fewer CD62L+ ILCP were present in PB of Crohn disease patients. These data are in agreement with selective expression of CD62L on nonactivated ILCP. As such, we conclude that CD62L not only serves as a functional marker of ILCP, but has potential to be used in the clinic as a diagnostic marker in inflammatory disorders.
Copyright © 2018 by The American Association of Immunologists, Inc.
Similar articles
-
Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients.Eur J Immunol. 2021 Jul;51(7):1792-1798. doi: 10.1002/eji.202048893. Epub 2021 Apr 7. Eur J Immunol. 2021. PMID: 33728641 Free PMC article.
-
Developmental options and functional plasticity of innate lymphoid cells.Curr Opin Immunol. 2017 Feb;44:61-68. doi: 10.1016/j.coi.2017.03.010. Epub 2017 Mar 28. Curr Opin Immunol. 2017. PMID: 28359987 Review.
-
Lead Impairs the Development of Innate Lymphoid Cells by Impeding the Differentiation of Their Progenitors.Toxicol Sci. 2020 Aug 1;176(2):410-422. doi: 10.1093/toxsci/kfaa074. Toxicol Sci. 2020. PMID: 32428222
-
Crohn's Disease Is Associated With Activation of Circulating Innate Lymphoid Cells.Inflamm Bowel Dis. 2021 Jun 15;27(7):1128-1138. doi: 10.1093/ibd/izaa316. Inflamm Bowel Dis. 2021. PMID: 33295628 Free PMC article.
-
Lineage specification in innate lymphocytes.Cytokine Growth Factor Rev. 2018 Aug;42:20-26. doi: 10.1016/j.cytogfr.2018.01.005. Epub 2018 Jan 12. Cytokine Growth Factor Rev. 2018. PMID: 29373198 Free PMC article. Review.
Cited by
-
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases.J Clin Invest. 2024 Sep 3;134(17):e178711. doi: 10.1172/JCI178711. J Clin Invest. 2024. PMID: 39225100 Free PMC article.
-
Bioprinted research models of urological malignancy.Exploration (Beijing). 2024 Feb 20;4(4):20230126. doi: 10.1002/EXP.20230126. eCollection 2024 Aug. Exploration (Beijing). 2024. PMID: 39175884 Free PMC article. Review.
-
Serum sSelectin-L is an early specific indicator of radiation injury.Heliyon. 2024 May 8;10(10):e30527. doi: 10.1016/j.heliyon.2024.e30527. eCollection 2024 May 30. Heliyon. 2024. PMID: 38778981 Free PMC article.
-
Circadian-clock-controlled endocrine and cytokine signals regulate multipotential innate lymphoid cell progenitors in the bone marrow.Cell Rep. 2024 May 28;43(5):114200. doi: 10.1016/j.celrep.2024.114200. Epub 2024 May 7. Cell Rep. 2024. PMID: 38717905 Free PMC article.
-
Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites.J Exp Med. 2023 Dec 4;220(12):e20221015. doi: 10.1084/jem.20221015. Epub 2023 Sep 29. J Exp Med. 2023. PMID: 37773047 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
