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. 2019 Jan 15:217:16-24.
doi: 10.1016/j.lfs.2018.11.038. Epub 2018 Nov 22.

RETRACTED: Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease

Yingjia Yao  1 , Yameng Wang  1 , Liang Kong  1 , Yuqing Chen  2 , Jingxian Yang  3
Affiliations

RETRACTED: Osthole decreases tau protein phosphorylation via PI3K/AKT/GSK-3β signaling pathway in Alzheimer's disease

Yingjia Yao et al. Life Sci. .

Retraction in

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of Editor-in-Chief. The corresponding author notified the journal of image duplications within the published article and requested a corrigendum. Specifically, the ‘APP/PS1’ plot in Figure 1A had appeared in a previous publication [Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells, Life Sciences (DOI: 10.1016/j.lfs.2019.03.070)], as the ‘TG’ plot in Figure 2A. In addition, several image duplications were identified within the panels of Figure 2. These issues, and others relating to unusual characteristics within the western blots, have been detailed here: https://pubpeer.com/publications/892AF7E4913255548C1446247FC65A#. As per journal policy when considering corrigendum requests, the journal requested the authors to provide explanations and source data relating to these affected figures. Upon receipt of additional source data, the editorial team noticed additional suspected image duplications. In relation to Figure 1A, the corresponding author stated that “…we mistakenly used the same Morris Water Maze data”, and a corrected figure was submitted. In relation to the image duplications within Figure 2, the corresponding author stated “…we mistakenly used the copy-and-paste tool instead of a color adjustment tool” during image post-processing. The corresponding author was unable to produce original unaltered and uncropped western blot source data. The editorial team have concerns about the provenance of the data and therefore the Editor-in-Chief decided to retract the article.

Keywords: Alzheimer's disease; Apoptosis; Osthole; PI3K; Phosphorylated tau protein.

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