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Review
. 2019 Jan;176(2):189-196.
doi: 10.1111/bph.14522. Epub 2018 Dec 9.

Endothelial NOS: perspective and recent developments

Victor Garcia  1 , William C Sessa  1
Affiliations
Review

Endothelial NOS: perspective and recent developments

Victor Garcia et al. Br J Pharmacol. 2019 Jan.

Abstract

Endothelial NOS (eNOS), and its product NO, are vital components of the control of vasomotor function and cardiovascular homeostasis. In the present review, we will take a deep dive into eNOS enzymology, function and mechanisms regulating endothelial NO. The mechanisms regulating eNOS and NO synthesis discussed here include alterations to transcriptional, post-translational modifications and protein-protein regulations. Also, we will discuss the phenotypes associated with various eNOS mutants and the consequences of a disrupted eNOS/NO cascade, highlighting the importance of eNOS function and vascular homeostasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.

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Figures

Figure 1
Figure 1
Diagram illustrating the various phosphorylation sites (stimulatory and inhibitory) located in human eNOS.
Figure 2
Figure 2
Diagram illustrating the phenotypes observed in eNOS mutant mice including eNOS S1176D, eNOS S1176A and the double mutant ApoE−/−/eNOS S1176A and ApoE−/−/eNOS KO mice.
See this image and copyright information in PMC

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