Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

doi:10.1007/s12035-018-1106-9

Review

. 2019 Feb;56(2):812-830.

doi: 10.1007/s12035-018-1106-9. Epub 2018 May 24.

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

Noralyn Basco Mañucat-Tan¹, Khalil Saadipour², Yan-Jiang Wang³, Larisa Bobrovskaya⁴, Xin-Fu Zhou⁵

Affiliations

¹ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia. noralyn.manucat@gmail.com.
² Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone School of Medicine, New York, NY, USA.
³ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
⁴ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia.
⁵ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia. Xin-Fu.Zhou@unisa.edu.au.

PMID: 29797184
DOI: 10.1007/s12035-018-1106-9

Review

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

Noralyn Basco Mañucat-Tan et al. Mol Neurobiol. 2019 Feb.

. 2019 Feb;56(2):812-830.

doi: 10.1007/s12035-018-1106-9. Epub 2018 May 24.

Authors

Noralyn Basco Mañucat-Tan¹, Khalil Saadipour², Yan-Jiang Wang³, Larisa Bobrovskaya⁴, Xin-Fu Zhou⁵

Affiliations

¹ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia. noralyn.manucat@gmail.com.
² Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry, Skirball Institute of Biomolecular Medicine, New York University Langone School of Medicine, New York, NY, USA.
³ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
⁴ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia.
⁵ School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5000, Australia. Xin-Fu.Zhou@unisa.edu.au.

PMID: 29797184
DOI: 10.1007/s12035-018-1106-9

Erratum in

Correction to: Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.
Mañucat-Tan NB, Saadipour K, Wang YJ, Bobrovskaya L, Zhou XF. Mañucat-Tan NB, et al. Mol Neurobiol. 2019 Feb;56(2):831-832. doi: 10.1007/s12035-018-1189-3. Mol Neurobiol. 2019. PMID: 29948951

Abstract

The accumulation of excess intracellular or extracellular amyloid beta (Aβ) is one of the key pathological events in Alzheimer's disease (AD). Aβ is generated from the cleavage of amyloid precursor protein (APP) by beta secretase-1 (BACE1) and gamma secretase (γ-secretase) within the cells. The endocytic trafficking of APP facilitates amyloidogenesis while at the cell surface, APP is predominantly processed in a non-amyloidogenic manner. Several adaptor proteins bind to both APP and BACE1, regulating their trafficking and recycling along the secretory and endocytic pathways. The phosphorylation of APP at Thr668 and BACE1 at Ser498, also influence their trafficking. Neurotrophins and proneurotrophins also influence APP trafficking through their receptors. In this review, we describe the molecular trafficking pathways of APP and BACE1 that lead to Aβ generation, the involvement of different signaling molecules or adaptor proteins regulating APP and BACE1 subcellular localization. We have also discussed how neurotrophins could modulate amyloidogenesis through their receptors.

Keywords: APP; Amyloidogenesis; BACE1; Cellular trafficking; Gamma-secretase.

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[1] Neurodegener Dis. 2006;3(4-5):262-9 - PubMed

[2] Neurodegener Dis. 2006;3(4-5):262-9 - PubMed

[3] Neurobiol Dis. 2005 Mar;18(2):399-408 - PubMed

[4] Neurobiol Dis. 2005 Mar;18(2):399-408 - PubMed

[5] Int J Mol Sci. 2015 Dec 10;16(12):29446-53 - PubMed

[6] Int J Mol Sci. 2015 Dec 10;16(12):29446-53 - PubMed

[7] Mol Cell Biol. 2015 Oct;35(19):3396-408 - PubMed

[8] Mol Cell Biol. 2015 Oct;35(19):3396-408 - PubMed

[9] J Med Chem. 2016 Aug 25;59(16):7389-409 - PubMed

[10] J Med Chem. 2016 Aug 25;59(16):7389-409 - PubMed

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Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

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