doi: 10.1016/j.bmcl.2018.04.029.
Epub 2018 Apr 12.
Synthesis of novel quinolinomatrine derivatives and their insecticidal/acaricidal activities
Affiliations
- PMID: 29685655
- DOI: 10.1016/j.bmcl.2018.04.029
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Synthesis of novel quinolinomatrine derivatives and their insecticidal/acaricidal activities
Bioorg Med Chem Lett.
.
Abstract
In continuation of our program to discover natural product-based pesticidal agents, a series of new quinolinomatrine derivatives were prepared. Especially three-dimensional structures of five compounds were unambiguously determined by single-crystal X-ray diffraction. Among them, 21-chloroquinolinomatrine exhibited good insecticidal and acaricidal activities against two crop-threatening insect pests, Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.
Keywords: Acaricidal activity; Insecticidal activity; Matrine; Quinoline.
Copyright © 2018 Elsevier Ltd. All rights reserved.
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