Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov;14(11):683-696.
doi: 10.1038/nrurol.2017.144. Epub 2017 Sep 12.

WNT signalling in prostate cancer

Virginia Murillo-Garzón  1 , Robert Kypta  1   2
Affiliations
Free article
Review

WNT signalling in prostate cancer

Virginia Murillo-Garzón et al. Nat Rev Urol. 2017 Nov.
Free article

Abstract

Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours - particularly in the development of castration-resistant prostate cancer. WNT signalling is also important in the prostate tumour microenvironment, in which WNT proteins secreted by the tumour stroma promote resistance to therapy, and in prostate cancer stem or progenitor cells, in which WNT-β-catenin signals promote self-renewal or expansion. Preclinical studies have demonstrated the potential of inhibitors that target WNT receptor complexes at the cell membrane or that block the interaction of β-catenin with lymphoid enhancer-binding factor 1 and the androgen receptor, in preventing prostate cancer progression. Some WNT signalling inhibitors are in phase I trials, but they have yet to be tested in patients with prostate cancer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63 - PubMed
    1. Cell. 2015 May 21;161(5):1215-1228 - PubMed
    1. Prostate. 2015 Sep;75(13):1363-75 - PubMed
    1. Cell. 2014 Jul 3;158(1):157-70 - PubMed
    1. PLoS One. 2011;6(10):e26539 - PubMed

MeSH terms