12h abstinence-induced right anterior insula network pattern changes in young smokers

doi:10.1016/j.drugalcdep.2017.02.019

. 2017 Jul 1:176:162-168.

doi: 10.1016/j.drugalcdep.2017.02.019. Epub 2017 May 15.

12h abstinence-induced right anterior insula network pattern changes in young smokers

Yanzhi Bi¹, Yajuan Zhang¹, Yangding Li², Dahua Yu³, Kai Yuan⁴, Jie Tian⁵

Affiliations

¹ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
² Guangxi Key Laboratory of Multi-source Information Mining and Security, Guangxi Normal University, Guilin, PR China.
³ Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China.
⁴ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China. Electronic address: kyuan@xidian.edu.cn.
⁵ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Institute of Automation, Chinese Academy of Sciences, Beijing, PR China. Electronic address: tian@ieee.org.

PMID: 28544994
DOI: 10.1016/j.drugalcdep.2017.02.019

12h abstinence-induced right anterior insula network pattern changes in young smokers

Yanzhi Bi et al. Drug Alcohol Depend. 2017.

. 2017 Jul 1:176:162-168.

doi: 10.1016/j.drugalcdep.2017.02.019. Epub 2017 May 15.

Authors

Yanzhi Bi¹, Yajuan Zhang¹, Yangding Li², Dahua Yu³, Kai Yuan⁴, Jie Tian⁵

Affiliations

¹ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China.
² Guangxi Key Laboratory of Multi-source Information Mining and Security, Guangxi Normal University, Guilin, PR China.
³ Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China.
⁴ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, PR China. Electronic address: kyuan@xidian.edu.cn.
⁵ School of Life Science and Technology, Xidian University, Xi'an, PR China; Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, PR China; Institute of Automation, Chinese Academy of Sciences, Beijing, PR China. Electronic address: tian@ieee.org.

PMID: 28544994
DOI: 10.1016/j.drugalcdep.2017.02.019

Abstract

Background: The strong craving to smoke is a core factor of smoking abstinence that precipitates relapse. Insula plays critical roles in maintaining nicotine dependence, especially in the interoceptive awareness of craving. Despite evidence indicating a link between insula and abstinence-induced craving, less is known about the neural basis of abstinence-induced craving from the circuit level of insula.

Methods: The present study examined the effects of 12h of abstinence from smoking on the resting state functional connectivity (RSFC) of anterior (AI) and posterior insula in young smokers using a within-subject design. Thirty-three young male smokers underwent functional magnetic resonance imaging scanning on two separate sessions: (1) smoking satiety and (2) abstinence (after ≥12h of smoking deprivation), in counterbalanced order. Multiple regression analysis was applied to investigate the possible relationships between the RSFC changes of insula (abstinence minus satiety) and the abstinence-induced craving changes.

Results: Smoking abstinence state (versus satiety) was associated with increased RSFC between right AI and right medial orbitofrontal cortex (OFC), ventromedial prefrontal cortex as well as anterior cingulate cortex. The abstinence-induced RSFC changes between right AI and right lateral OFC was significantly correlated with the craving changes.

Conclusions: These findings improve the understanding of the effects of short-term smoking abstinence on insula circuit connectivity and may contribute new insights into the neural basis of abstinence-induced craving to smoke.

Keywords: Abstinence-induced craving; Insula; Orbitofrontal cortex; Resting state functional connectivity; Young smoker.

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12h abstinence-induced right anterior insula network pattern changes in young smokers

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12h abstinence-induced right anterior insula network pattern changes in young smokers

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