Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;17(4):223-238.
doi: 10.1038/nrc.2017.7. Epub 2017 Feb 24.

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C M Wan  1   2 , Charles Massie  1   2 , Javier Garcia-Corbacho  3 , Florent Mouliere  1   2 , James D Brenton  1   2 , Carlos Caldas  1   2   4 , Simon Pacey  2   4 , Richard Baird  2   4 , Nitzan Rosenfeld  1   2
Affiliations
Free article
Review

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C M Wan et al. Nat Rev Cancer. 2017 Apr.
Free article

Abstract

Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA. This is an opportune time to appraise potential approaches to ctDNA analysis, and to consider their applications in personalized oncology and in cancer research.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Thorac Oncol. 2014 Sep;9(9):1345-53 - PubMed
    1. Exerc Immunol Rev. 2015;21:164-73 - PubMed
    1. Clin Cancer Res. 2016 Feb 15;22(4):915-22 - PubMed
    1. Cancer. 2014 Dec 15;120(24):3896-901 - PubMed
    1. Sci Transl Med. 2010 Dec 8;2(61):61ra91 - PubMed