Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016:2016:5380792.
doi: 10.1155/2016/5380792. Epub 2016 Dec 21.

Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

Simona Vachatova  1 , Ctirad Andrys  2 , Jan Krejsek  2 , Miloslav Salavec  1 , Karel Ettler  1 , Vit Rehacek  3 , Eva Cermakova  4 , Andrea Malkova  5 , Zdenek Fiala  5 , Lenka Borska  6
Affiliations

Metabolic Syndrome and Selective Inflammatory Markers in Psoriatic Patients

Simona Vachatova et al. J Immunol Res. 2016.

Abstract

The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI (p < 0.05) and diastolic blood pressure (p < 0.05) in the psoriatic patients. The values of waist circumference and BMI were significantly higher (p < 0.05) in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP (p < 0.001), Lp-PLA2 (p < 0.001), leptin (p < 0.01), and resistin (p < 0.01) levels in the psoriatic patients. Significantly higher levels of CRP (p < 0.01), Lp-PLA2 (p < 0.001), leptin (p < 0.01), and resistin (p < 0.05) were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower (p < 0.01) in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 (p < 0.001) in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests regarding the publication of this paper.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Parisi R., Symmons D. P. M., Griffiths C. E. M., Ashcroft D. M. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. Journal of Investigative Dermatology. 2013;133(2):377–385. doi: 10.1038/jid.2012.339. - DOI - PubMed
    1. Deng Y., Chang C., Lu Q. The inflammatory response in psoriasis: a comprehensive review. Clinical Reviews in Allergy & Immunology. 2016;50(3):377–389. doi: 10.1007/s12016-016-8535-x. - DOI - PubMed
    1. Borska L., Andrys C., Krejsek J., et al. Serum level of antibody against benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in people dermally exposed to PAHs. Journal of Immunology Research. 2014;2014:6. doi: 10.1155/2014/834389.834389 - DOI - PMC - PubMed
    1. Machado-Pinto J., Diniz M. d., Bavoso N. C. Psoriasis: new comorbidities. Anais Brasileiros de Dermatologia. 2016;91(1):8–14. doi: 10.1590/abd1806-4841.20164169. - DOI - PMC - PubMed
    1. Grozdev I., Korman N., Tsankov N. Psoriasis as a systemic disease. Clinics in Dermatology. 2014;32(3):343–350. doi: 10.1016/j.clindermatol.2013.11.001. - DOI - PubMed

MeSH terms