Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec 2;25(12):732-739.
doi: 10.12968/jowc.2016.25.12.732.

Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing

M Buzzi  1 , F de Freitas  2 , M de Barros Winter  3
Affiliations

Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing

M Buzzi et al. J Wound Care. .

Abstract

Objective: Non-healing venous leg ulcers (VLUs) have a significant effect on patients' quality of life and substantially increase expenditures in health-care systems. The aim of this study was to evaluate the clinical efficacy of the Calendula officinalis extract, Plenusdermax, in the treatment of VLUs.

Method: Patients treated with Calendula officinalis extract (n=38) and control patients (n=19) were evaluated every two weeks for 30 weeks or until their ulcers healed. Assessments included determination of the wound area by planimetry, infection control, and evaluation of the clinical aspects of the wounds. The percentage of healing velocity per week (%HVw), taking the initial area at baseline into account, was also determined.

Results: The proportion of the treatment patients achieving complete epithelialisation was 72 % and 32 % in the treatment and control groups, respectively. The average healing time was approximately 12 weeks in the treatment group and 25 % in control patients. Patients with ulcers treated with Calendula officinalis extract had a significant 4-fold increase in percentage healing velocity per week, 7.4 %, compared with 1.7 % in the control group. No adverse events were observed during the Calendula officinalis extract treatment.

Conclusion: Our findings indicate that Calendula officinalis extract is an effective treatment for VLUs.

Declaration of interest: The authors have no conflict of interest.

Keywords: bioactive fraction of Calendula officinalis; chronic ulcers; venous leg ulcer; wound healing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources