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Case Reports
. 2016;21(10):30159.
doi: 10.2807/1560-7917.ES.2016.21.10.30159.

Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016

Luisa Barzon  1 , Monia Pacenti, Alessandro Berto, Alessandro Sinigaglia, Elisa Franchin, Enrico Lavezzo, Pierluigi Brugnaro, Giorgio Palù
Affiliations
Free article
Case Reports

Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016

Luisa Barzon et al. Euro Surveill. 2016.
Free article

Abstract

We report the isolation of infectious Zika virus (ZIKV) in cell culture from the saliva of a patient who developed a febrile illness after returning from the Dominican Republic to Italy, in January 2016. The patient had prolonged shedding of viral RNA in saliva and urine, at higher load than in blood, for up to 29 days after symptom onset. Sequencing of ZIKV genome showed relatedness with strains from Latin America.

Keywords: Zika virus; diagnosis; genome sequencing; saliva; transmission; virus isolation.

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