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Review
. 2016 Jun;468(6):935-43.
doi: 10.1007/s00424-016-1803-z. Epub 2016 Mar 3.

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

Márta Széll  1   2 , Judit Danis  3 , Zsuzsanna Bata-Csörgő  4   3 , Lajos Kemény  4   3
Affiliations
Review

PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis

Márta Széll et al. Pflugers Arch. 2016 Jun.

Abstract

In the last few years with the recent emergence of high-throughput technologies, thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome. However, assigning functional annotation and determining cellular contexts for these RNAs are still in its infancy. As information gained about lncRNA structure, interacting partners, and roles in human diseases may be helpful in the characterization of novel lncRNAs, we review our knowledge on a selected group of lncRNAs that were identified serendipitously years ago by large-scale gene expression methods used to study human diseases. In particular, we focus on the Psoriasis-susceptibility-Related RNA Gene Induced by Stress (PRINS) lncRNA, first identified by our research group as a transcript highest expressed in psoriatic non-lesional epidermis. Results gathered for PRINS in the last 10 years indicate that it is conserved in primates and plays a role in keratinocyte stress response. Elevated levels of PRINS expression in psoriatic non-lesional keratinocytes alter the stress response of non-lesional epidermis and contribute to disease pathogenesis. Finally, we propose a categorization for the PRINS lncRNA based on a recently elaborated system for lncRNA classification.

Keywords: Keratinocyte stress response; PRINS; Primate specific; Psoriasis; lncRNA.

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Figures

Fig. 1
Fig. 1
Major characteristics of the PRINS lncRNA. a Putative secondary structure of the PRINS lncRNA. b Similarity search identified three Alu elements within the PRINS lncRNA sequence. The PRINS gene is localized on the p12.1 arm of human Chr. 10, which is highly conserved in human and four other primate species. Although partial sequence similarity was found, it is largely due to the conservation of Alu elements. In other primate species, the PRINS sequence was distributed on other chromosomes. c UVB irradiation induces the shuttling of nucleophosmin (NPM) from the nucleolus to the nucleoplasm. Silencing of the PRINS lncRNA, which physically interacts with NPM, results in the retention in the nucleolus
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