Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jan;47(1):304-19.
doi: 10.1183/13993003.01824-2014. Epub 2015 Dec 17.

Asthma phenotypes and IgE responses

Antoine Froidure  1 , Jonathan Mouthuy  1 , Stephen R Durham  2 , Pascal Chanez  3 , Yves Sibille  4 , Charles Pilette  5
Affiliations
Free article
Review

Asthma phenotypes and IgE responses

Antoine Froidure et al. Eur Respir J. 2016 Jan.
Free article

Abstract

The discovery of IgE represented a major breakthrough in allergy and asthma research, whereas the clinical interest given to IgE in asthma has been blurred until the arrival of anti-IgE biotherapy. Novel facets of the complex link between IgE and asthma have been highlighted by the effect of this treatment and by basic research. In parallel, asthma phenotyping recently evolved to the concept of endotypes, relying on identified/suspected pathobiological mechanisms to phenotype patients, but has not yet clearly positioned IgE among biomarkers of asthma.In this review, we first summarise recent knowledge about the regulation of IgE production and its main receptor, FcεRI. In addition to allergens acting as classical IgE inducers, viral infections as well as air pollution may trigger the IgE pathway, notably resetting the threshold of IgE sensitivity by regulating FcεRI expression. We then analyse the place of IgE in different asthma endo/phenotypes and discuss the potential interest of IgE among biomarkers in asthma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles