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Review
. 2015 Nov 10;6(15):1296-308.
doi: 10.4239/wjd.v6.i15.1296.

Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity

Chandra Kanti Chakraborti  1
Affiliations
Review

Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity

Chandra Kanti Chakraborti. World J Diabetes. .

Abstract

Because of the intimate association of obesity with type 2 diabetes mellitus (T2DM), during the last two decades, extensive research work is being conducted to find out whether the coexistence of the two is a simple association or there is a positive correlating link between the two. In this article, an attempt has been made to collect and analyse the recent developments in this field and to arrive at a conclusion on the subject. The possible role of several important factors (obtained from adipocytes/not of adipocyte origin) in linking the two has been discussed in detail. Some of the agents, specifically adiponectin, are beneficial (i.e., reduce the incidence of both), while others are harmful (i.e., increase their incidence). From the analysis, it appears that obesity and T2DM are intimately linked.

Keywords: Adipocyte; Insulin; Insulin resistance; Obesity; Type 2 diabetes mellitus.

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Figures

Figure 1
Figure 1
Cytokines linking type 2 diabetes mellitus with obesity. TNF-α: Tumour necrosis factor-alpha; IL-6: Interleukin-6; RBP-4: Retinol binding protein-4; DPP-4: Dipeptidyl peptidase-4; FFA: Free fatty acid; PPAR: Peroxisome proliferator-activated receptor; Ang II: Angiotensin II; TLRs: Toll-like receptors; T2DM: Type 2 diabetes mellitus; PAI-1: Plasminogen activator inhibitor-1.
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