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Review
. 2016 Mar;39(3):259-63.
doi: 10.1007/s40618-015-0336-1. Epub 2015 Jun 24.

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?

R Valentino  1 , V D'Esposito  2 , F Ariemma  2 , I Cimmino  2 , F Beguinot  3   2 , P Formisano  3   2
Affiliations
Review

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?

R Valentino et al. J Endocrinol Invest. 2016 Mar.

Abstract

In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable periods, such as foetal and neonatal life. The BPA source of contamination can occur via food, beverage, wastewater, air, dust and soil. BPA, as lipophilic compound, may accumulate into the adipose tissue already during foetal life and may affect adulthood health, through adverse effects on the growth and development of organs and tissues. Thus, based on several studies, it would be crucial to consider further actions aimed to refine risk assessment at least in vulnerable population, such as foetuses, infants and young children, to prevent metabolic diseases and obesity.

Keywords: Bisphenol A; Endocrine disruptors; Insulin resistance; Low-grade-inflammation; Obesity; Prenatal/neonatal exposure.

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Figures

Fig. 1
Fig. 1
Putative scheme on bisphenol A (BPA) action in adipocyte. BPA can bind oestrogen receptors and/or TLR/cytokine receptors. BPA may modulate cytokine synthesis by activation of JNK/STAT3/NFkB inflammatory pathway, and by influencing insulin network via IR/AKT down-regulation
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References

    1. Pereira-Fernandes A, Demaegdt H, Vandermeiren K, Hectors TL, Jorens PG, Blust R, Vanparys C. Evaluation of a screening system for obesogenic compounds: screening of endocrine disrupting compounds and evaluation of the PPAR dependency of the effect. PLoS One. 2013 - PMC - PubMed
    1. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA) Reprod Toxicol. 2007;24(2):139–177. doi: 10.1016/j.reprotox.2007.07.010. - DOI - PubMed
    1. Wetherill YB, Akingbemi BT, Kanno J, McLachlan JA, Nadal A, Sonnenschein C, Watson CS, Zoeller RT, Belcher SM. In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol. 2007;24(2):178–198. doi: 10.1016/j.reprotox.2007.05.010. - DOI - PubMed
    1. Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol. 2013;42:132–155. doi: 10.1016/j.reprotox.2013.08.008. - DOI - PubMed
    1. Kang JH, Kondo F, Katayama Y. Human exposure to bisphenol A. Toxicology. 2006;226(2–3):79–89. doi: 10.1016/j.tox.2006.06.009. - DOI - PubMed

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