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Meta-Analysis
. 2015 Jun 2;10(6):e0128642.
doi: 10.1371/journal.pone.0128642. eCollection 2015.

Prognostic Value and Clinicopathology Significance of MicroRNA-200c Expression in Cancer: A Meta-Analysis

Jianchun Wu  1 , Zhihong Fang  1 , Jing Xu  1 , Weikang Zhu  1 , Yan Li  1 , Yongchun Yu  2
Affiliations
Meta-Analysis

Prognostic Value and Clinicopathology Significance of MicroRNA-200c Expression in Cancer: A Meta-Analysis

Jianchun Wu et al. PLoS One. .

Abstract

MiR-200c has been shown to be related to cancer formation and progression. However, the prognostic and clinicopathologic significance of miR-200c expression in cancer remain inconclusive. We carried out this systematic review and meta-analysis to investigate the prognostic value of miR-200c expression in cancer. Pooled hazard ratios (HRs) of miR-200c for overall survival (OS) and progression-free survival (PFS) were calculated to measure the effective value of miR-200c expression on prognosis. The association between miR-200c expression and clinical significance was measured by odds ratios (ORs). Twenty-three studies were included in our meta-analysis. We found that miR-200c was not significantly correlated with OS (HR = 1.41, 95%Cl: 0.95-2.10; P = 0.09) and PFS (HR = 1.12, 95%Cl: 0.68-1.84; P = 0.67) in cancer. In our subgroup analysis, higher expression of miR-200c was significantly associated with poor OS in blood (HR = 2.10, 95%CI: 1.52-2.90, P<0.00001). Moreover, in clinicopathology analysis, miR-200c expression in blood was significantly associated with TNM stage, lymph node metastasis and distant metastasis. MiR-200c may have the potential to become a new blood biomarker to monitor cancer prognosis and progression.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram summarizing the selection of eligible studies.
Fig 2
Fig 2. Meta-analysis evaluating miR-200c expression and overall survival (OS) in cancer patients.
Fig 3
Fig 3. Meta-analysis evaluating miR-200c expression and overall survival (OS) for blood samples.
Fig 4
Fig 4. Meta-analysis evaluating miR-200c expression and lymph node metastasis in cancer patients.
Fig 5
Fig 5. Meta-analysis evaluating miR-200c expression and distant metastasis in cancer patients.
Fig 6
Fig 6. Meta-analysis evaluating miR-200c expression and TNM stage for blood samples.
See this image and copyright information in PMC

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References

    1. Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM, et al. (2002) Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet 11: 1399–1407. - PubMed
    1. Ma X, Liu L, Nie W, Li Y, Zhang B, Zhang J, et al. (2013) Prognostic role of caveolin in breast cancer: a meta-analysis. Breast 22: 462–469. 10.1016/j.breast.2013.03.005 - DOI - PubMed
    1. Dai J, Tang K, Xiao W, Yu G, Zeng J, Li W, et al. (2014) Prognostic significance of C-reactive protein in urological cancers: a systematic review and meta-analysis. Asian Pac J Cancer Prev 15: 3369–3375. - PubMed
    1. Zeng R, Duan L, Kong Y, Liang Y, Wu X, Wei X, et al. (2013) Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis. Chin J Cancer Res 25: 637–645. 10.3978/j.issn.1000-9604.2013.11.03 - DOI - PMC - PubMed
    1. Yang H, Chen B (2013) CD147 in ovarian and other cancers. Int J Gynecol Cancer 23: 2–8. 10.1097/IGC.0b013e3182749139 - DOI - PubMed

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Grants and funding

This study was supported by Natural Science Foundation of China (Grant Nos: 31171086). The funders Yongchun Yu designed this research.

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