Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul;159(1):107-17.
doi: 10.1016/j.clim.2015.04.010. Epub 2015 Apr 27.

Polarization diversity of human CD4+ stem cell memory T cells

Masaru Takeshita  1 , Katsuya Suzuki  2 , Yoshiaki Kassai  3 , Maiko Takiguchi  4 , Yusuke Nakayama  5 , Yuki Otomo  6 , Rimpei Morita  7 , Takahiro Miyazaki  8 , Akihiko Yoshimura  9 , Tsutomu Takeuchi  10
Affiliations

Polarization diversity of human CD4+ stem cell memory T cells

Masaru Takeshita et al. Clin Immunol. 2015 Jul.

Abstract

T cells are considered to develop through three stages, from naïve T (Tn) into central memory T (Tcm) and finally into effector memory T (Tem). Among the subsets of Tn, stem cell memory T (Tscm) were recently found to be the least developed memory subset. While this subset was revealed to possess self-reproducibility and multipotentiality, little is known about the relationship between development and polarity. We conducted transcriptome analysis of human CD4(+) T subsets and found that Tscm was a clearly distinct subset, located between Tn and Tcm. Surface antigen analysis and differentiation assay showed that the flexibility of polarity and the cytokine production progressively changed as the differentiation of CD4(+) T cells advanced. Interestingly, we found that most cells of the CD45RO(-)CCR7(+)CCR6(+) subset, hitherto considered the naïve precursor of Th17, were in fact Tscm. These findings may advance our understanding of the highly heterogeneous human helper T cells.

Keywords: Helper T cell; Stem cell memory T; Th17 precursor.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms